Ketipramine

Ketipramine
Clinical data
Routes of
administration		Oral
ATC code
  • none
Identifiers
  • 5-[3-(dimethylamino)propyl]-5,11-dihydro-10H-dibenzo[b,f]azepin-10-one
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC19H22N2O
Molar mass294.398 g·mol−1
3D model (JSmol)
  • O=C3c1c(cccc1)N(c2c(cccc2)C3)CCCN(C)C

Ketipramine (G-35,259), also known as ketimipramine or ketoimipramine, is a tricyclic antidepressant (TCA) that was tested in clinical trials for the treatment of depression in the 1960s but was never marketed.[1][2][3] It differs from imipramine in terms of chemical structure only by the addition of a ketone group, to the azepine ring, and is approximately equivalent in effectiveness as an antidepressant in comparison.[4]

It was one of the drugs prescribed by Roland Kuhn in a series of unethical experiments to test drugs on children without informed consent and without proper approval at the psychiatric hospital in Münsterlingen, Switzerland.[5][6][7]

See also

References

  1. ^ Dictionary of organic compounds. London: Chapman & Hall. 1996. ISBN 0-412-54090-8.
  2. ^ Simeon J, Fuchs M, Nikolovski O, Bucci L (1970). "Ketipramine in the therapy of depression in outpatients". Psychosomatics. 11 (4): 342–6. doi:10.1016/S0033-3182(70)71634-4. PMID 5459338. Archived from the original on 2011-07-27.
  3. ^ Park S, Glick B, Floyd A, Gershon S (May 1971). "Ketipramine fumarate as compared to imipramine in depressed outpatients". Current Therapeutic Research, Clinical and Experimental. 13 (5): 322–5. PMID 4998396.
  4. ^ Author Unknown (1971). Ann Reports Medicinal Chem V6 (v. 6). Boston: Academic Press. ISBN 0-12-040506-7. {{cite book}}: |author= has generic name (help)
  5. ^ Die Experimente von Münsterlingen 20. November 2012. Tages-Anzeiger
  6. ^ Münsterlingen: Alles noch viel schlimmer
  7. ^ Simone Rau: Das Ausmass der Medi-Versuche in Münsterlingen ist weit grösser. In: Der Bund, 31. Oktober 2016.