As for style of play, Adrien said in an interview that he feels the best attributes that he brings to the game are his "leadership, rebounding, toughness, and the ability to score over taller guys". Adrien indeed demonstrated potential as a rebounder over taller players in the NBA pre-draft measurements; despite measuring shorter than average for a power forward for the NBA draft at 6'6.5" with shoes on, Adrien's wingspan measures an outstanding 7'2" and he weighed in at a formidable 236 lbs.[11]
On August 24, 2010, Adrien was invited to the Golden State Warriors training camp.[13] On October 10, 2010, Adrien scored 11 points and grabbed 15 rebounds in 22 minutes in a preseason game against the Sacramento Kings[14] He made the Warriors' final roster, but was waived in December 2010 to make room for Acie Law.[15]
On December 21, 2011, Adrien signed with the Houston Rockets, where he was reunited with his former University of Connecticut teammate Hasheem Thabeet.[17] He was waived on February 8, 2012.[18]
On December 9, 2012, he was called up to play with the Charlotte Bobcats, where he was again reunited with a former University of Connecticut teammate in Kemba Walker.[20] On January 8, 2013 the Bobcats guaranteed Adrien's contract for the remainder of the season.[21]
On July 19, 2014, Adrien signed with the Houston Rockets, returning for a second stint.[23] However, he was later waived by the Rockets on October 27, 2014.[24]
On November 29, 2014, Adrien signed with the Minnesota Timberwolves to help the team deal with numerous injuries. Minnesota had to use an NBA hardship exemption in order to sign him as he made their roster stand at 16, one over the allowed limited of 15.[25] On January 7, 2015, he was waived by the Timberwolves after appearing in 17 games.[26]
On September 23, 2015, Adrien signed with the New Orleans Pelicans.[29] However, he was later waived by the Pelicans on October 24 after appearing in three preseason games.[30]
2016–17 season
On August 22, 2016, Adrien signed with Bnei Herzliya of the Israeli Premier League.[31] During his season with the club, he was selected to the Israeli League All-Star game and helped the club reach the FIBA Europe Cup second round. However, despite their outstanding regular season with 76% home game victories, the team who ended the league at the fifth place didn't manage to win in the play-offs.
2017–18 season
On August 24, 2017, Adrien signed a two-year contract extension with Bnei Herzliya.[32] On October 18, 2017, Adrien recorded a double-double of 26 points and 15 rebounds, shooting 12-of-15 from the field, in a 93–74 win over Alba Fehérvár. He was subsequently named FIBA Europe Cup round 1 Top Performer.[33] On March 29, 2018, Adrien was named Israeli League Player of the Month for games played in March.[34] On April 8, 2018, Adrien recorded a career-high 31 points, shooting 10-of-17 from the field, along with 10 rebounds and 2 steals in an 86–78 win over Hapoel Jerusalem.[35] Adrien finished his second season with Herzliya as the Israeli League fifth-leading scorer with 17.2 points per game, third in rebounds with 8.8 per game and third in efficiency rating with 21.2 per game.
2018–19 season
On July 3, 2018, Adrien signed a three-year contract extension with Bnei Herzliya.[36][37] On March 7, 2019, Adrien recorded a season-high 25 points, shooting 9-of-14 from the field, along with 12 rebounds and four assists in an 89–90 loss to Hapoel Gilboa Galil.[38] That season, Bnei Herzliya have finished the season in the last place out of 12 teams and was relegated to the Israeli National League (the second-tier league in Israel).
2019–20 season
On August 28, 2019, Adrien signed with Ironi Nahariya for the 2019–20 season.[39] In 14 games played for Nahariya, he averaged 10.9 and 6.4 rebounds per game. On January 7, 2020, he parted ways with Nahariya.[40]