Isoliquiritigenin 2'-O-methyltransferase

Isoliquiritigenin 2'-O-methyltransferase
Identifiers
EC no.	2.1.1.154
CAS no.	139317-14-9
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

In enzymology, an isoliquiritigenin 2'-O-methyltransferase (EC 2.1.1.154) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + isoliquiritigenin ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + 2'-O-methylisoliquiritigenin

Thus, the two substrates of this enzyme are S-adenosyl methionine and isoliquiritigenin, whereas its two products are S-adenosylhomocysteine and 2'-O-methylisoliquiritigenin.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:isoliquiritigenin 2'-O-methyltransferase. Other names in common use include chalcone OMT, and CHMT.

References

• Maxwell CA, Edwards R, Dixon RA (1992). "Identification, purification, and characterization of S-adenosyl-L-methionine: isoliquiritigenin 2'-O-methyltransferase from alfalfa (Medicago sativa L.)". Arch. Biochem. Biophys. 293 (1): 158–66. doi:10.1016/0003-9861(92)90379-B. PMID 1731632.
• Ichimura M, Furuno T, Takahashi T, Dixon RA, Ayabe S (1997). "Enzymic O-methylation of isoliquiritigenin and licodione in alfalfa and licorice cultures". Phytochemistry. 44 (6): 991–5. doi:10.1016/S0031-9422(96)00670-X. PMID 9055445.