Interferon gamma 5' UTR regulatory element

Interferon gamma 5' UTR regulatory element
Predicted secondary structure and sequence conservation of IFN_gamma
Identifiers
Symbol	IFN_gamma
Rfam	RF00259
Other data
RNA type	Cis-reg
Domain(s)	Eukaryota
SO	SO:0000204
PDB structures	PDBe

Interferon gamma 5' UTR regulatory elements are a family of regulatory RNAs. This family represents a pseudoknot containing stem-loop structure found in the 5' UTR of interferon-gamma mRNA. This structure is thought to be involved in translational regulation and the pseudoknot has been found to activate protein kinase R (PKR) which is known to be a translational inhibitor. Mutations in the pseudoknot structure have been found to reduce PKR activation and increase the translation of interferon-gamma.^[1]

References

1. Ben-Asouli Y, Banai Y, Pel-Or Y, Shir A, Kaempfer R (January 2002). "Human interferon-gamma mRNA autoregulates its translation through a pseudoknot that activates the interferon-inducible protein kinase PKR". Cell. 108 (2): 221–232. doi:10.1016/S0092-8674(02)00616-5. PMID 11832212.

External links

• Page for Interferon gamma 5' UTR regulatory element at Rfam