Interferon-induced transmembrane protein 2

IFITM2
Identifiers
Aliases	IFITM2, 1-8D, DSPA2c, interferon induced transmembrane protein 2
External IDs	OMIM: 605578; MGI: 1933382; HomoloGene: 74574; GeneCards: IFITM2; OMA:IFITM2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.5 Start 303,655 bp[1] End 309,397 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F5 Start 140,534,750 bp[2] End 140,535,900 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood right lung pericardium periodontal fiber spleen upper lobe of left lung left uterine tube Descending thoracic aorta olfactory bulb granulocyte Top expressed in adrenal gland granulocyte uterus lung urinary bladder lip white adipose tissue zone of skin heart epiblast More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 10581 80876 Ensembl ENSG00000185201 ENSMUSG00000060591 UniProt Q01629 Q99J93 RefSeq (mRNA) NM_006435 NM_030694 RefSeq (protein) NP_006426 NP_109619 Location (UCSC) Chr 11: 0.3 – 0.31 Mb Chr 7: 140.53 – 140.54 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interferon-induced transmembrane protein 2 is a protein that in humans is encoded by the IFITM2 gene.^[5] IFITM1 is a member of the IFITM family (Interferon-induced transmembrane protein) which is encoded by IFITM genes.

As the name implies, these genes are induced by interferon and form part of its signaling pathway. In the absence of interferon stimulation, IFITM proteins can express broadly in tissues and cell lines. In humans, IFITM1, IFITM2 and IFITM3 are able to express in different tissues and cells while the expression of IFITM5 is limited to osteoblasts.^[6]

Antiviral function

Further information: IFITM1 § Antiviral function of IFITM proteins

IFITM proteins have been identified as antiviral restriction factors that block the early stages of viral replication.^[7] They inhibit influenza A virus replication,^[8] and infection with a wide range of other enveloped viruses^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000185201 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000060591 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Interferon induced transmembrane protein 2". Retrieved 2016-02-21.
6. Tanaka SS, Yamaguchi YL, Tsoi B, Lickert H, Tam PP (December 2005). "IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion". Dev. Cell. 9 (6): 745–56. doi:10.1016/j.devcel.2005.10.010. PMID 16326387.
7. Li K, Markosyan RM, Zheng YM, Golfetto O, Bungart B, Li M, Ding S, He Y, Liang C, Lee JC, Gratton E, Cohen FS, Liu SL (January 2013). "IFITM proteins restrict viral membrane hemifusion". PLOS Pathog. 9 (1): e1003124. doi:10.1371/journal.ppat.1003124. PMC 3554583. PMID 23358889.
8. Feeley EM, Sims JS, John SP, Chin CR, Pertel T, Chen LM, Gaiha GD, Ryan BJ, Donis RO, Elledge SJ, Brass AL (October 2011). "IFITM3 inhibits influenza A virus infection by preventing cytosolic entry". PLOS Pathog. 7 (10): e1002337. doi:10.1371/journal.ppat.1002337. PMC 3203188. PMID 22046135.
9. Brass AL, Huang IC, Benita Y, John SP, Krishnan MN, Feeley EM, Ryan BJ, Weyer JL, van der Weyden L, Fikrig E, Adams DJ, Xavier RJ, Farzan M, Elledge SJ (December 2009). "The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus". Cell. 139 (7): 1243–54. doi:10.1016/j.cell.2009.12.017. PMC 2824905. PMID 20064371.

Further reading