Histidinol-phosphatase

histidinol-phosphatase
Histidinol-phosphatase tetramer, Thermus thermophilus
Identifiers
EC no.	3.1.3.15
CAS no.	9025-79-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The enzyme histidinol-phosphatase (EC 3.1.3.15) catalyzes the reaction

L-histidinol phosphate + H₂O ${\displaystyle \rightleftharpoons }$ L-histidinol + phosphate

This enzyme participates in histidine metabolism.

Nomenclature

This enzyme belongs to the family of hydrolases, to be specific, those acting on phosphoric monoester bonds. The systematic name is L-histidinol-phosphate phosphohydrolase. Other names in common use include histidinol phosphate phosphatase, L-histidinol phosphate phosphatase, histidinolphosphate phosphatase, HPpase, and histidinolphosphatase.

E. coli

Main article: hisB

In E. coli the enzyme encoded by the gene hisB is a fused imidazoleglycerol-phosphate dehydratase and histidinol-phosphatase.^[1]

References

1. Brilli M, Fani R (February 2004). "Molecular evolution of hisB genes". Journal of Molecular Evolution. 58 (2): 225–237. Bibcode:2004JMolE..58..225B. doi:10.1007/s00239-003-2547-x. PMID 15042344. S2CID 1684458.

Further reading

• Ames BN (June 1957). "The biosynthesis of histidine; L-histidinol phosphate phosphatase". The Journal of Biological Chemistry. 226 (2): 583–593. doi:10.1016/S0021-9258(18)70840-5. PMID 13438843.