High-mannose-oligosaccharide β-1,4-N-acetylglucosaminyltransferase

High-mannose-oligosaccharide β-1,4-N-acetylglucosaminyltransferase
Identifiers
EC no.	2.4.1.197
CAS no.	123425-54-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

High-mannose-oligosaccharide β-1,4-N-acetylglucosaminyltransferase (EC 2.4.1.197), uridine diphosphoacetylglucosamine-oligosaccharide acetylglucosaminyltransferase, acetylglucosamine-oligosaccharide acetylglucosaminyltransferase, UDP-GlcNAc:oligosaccharide beta-N-acetylglucosaminyltransferase, UDP-N-acetyl-D-glucosamine:high-mannose-oligosaccharide beta-1,4-N-acetylglucosaminyltransferase) is an enzyme with systematic name UDP-N-acetyl-D-glucosamine:high-mannose-oligosaccharide 4-beta-N-acetylglucosaminyltransferase.^[1] This enzyme catalyses the following chemical reaction

Transfers an N-acetyl-D-glucosamine residue from UDP-N-acetyl-D-glucosamine to the 4-position of a mannose linked alpha-(1->6) to the core mannose of high-mannose oligosaccharides produced by Dictyostelium discoideum

The activity of the intersecting mannose residue as acceptor is dependent on two other mannose residues attached by alpha-1,3 and alpha-1,6 links.

References

1. Sharkey DJ, Kornfeld R (June 1989). "Identification of an N-acetylglucosaminyltransferase in Dictyostelium discoideum that transfers an "intersecting" N-acetylglucosamine residue to high mannose oligosaccharides". The Journal of Biological Chemistry. 264 (18): 10411–9. PMID 2525124.

External links

• High-mannose-oligosaccharide+beta-1,4-N-acetylglucosaminyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)