HIV-2 protease

HIV-2 retropepsin
Identifiers
EC no.	3.4.23.47
CAS no.	144114-21-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

HIV-2 protease or retropepsin (EC 3.4.23.47) is an enzyme.^[1][2] This enzyme catalyses the following chemical reaction

Endopeptidase for which the P1 residue is preferably hydrophobic

This enzyme belongs to the peptidase family A2.

References

1. Tözsér J, Bláha I, Copeland TD, Wondrak EM, Oroszlan S (April 1991). "Comparison of the HIV-1 and HIV-2 proteinases using oligopeptide substrates representing cleavage sites in Gag and Gag-Pol polyproteins". FEBS Letters. 281 (1–2): 77–80. doi:10.1016/0014-5793(91)80362-7. PMID 2015912.
2. Chen Z, Li Y, Chen E, Hall DL, Darke PL, Culberson C, Shafer JA, Kuo LC (October 1994). "Crystal structure at 1.9-A resolution of human immunodeficiency virus (HIV) II protease complexed with L-735,524, an orally bioavailable inhibitor of the HIV proteases". The Journal of Biological Chemistry. 269 (42): 26344–8. doi:10.1016/S0021-9258(18)47199-2. PMID 7929352.

External links

• HIV-2+retropepsin at the U.S. National Library of Medicine Medical Subject Headings (MeSH)