HIPK3

HIPK3
Identifiers
Aliases	HIPK3, DYRK6, FIST3, PKY, YAK1, homeodomain interacting protein kinase 3
External IDs	OMIM: 604424; MGI: 1314882; HomoloGene: 55923; GeneCards: HIPK3; OMA:HIPK3 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p13 Start 33,256,672 bp[1] End 33,357,023 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 E2 Start 104,256,826 bp[2] End 104,324,791 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell Skeletal muscle tissue of biceps brachii right ventricle parietal pleura tail of epididymis Skeletal muscle tissue of rectus abdominis visceral pleura germinal epithelium gingival epithelium saphenous vein Top expressed in vastus lateralis muscle atrioventricular valve triceps brachii muscle atrium ankle left lung lobe temporal muscle sternocleidomastoid muscle intercostal muscle digastric muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function kinase activity transferase activity protein kinase activity nucleotide binding protein serine/threonine kinase activity ATP binding Cellular component PML body nucleus cytoplasm cytosol nuclear body Biological process protein phosphorylation mRNA transcription peptidyl-threonine phosphorylation regulation of transcription, DNA-templated negative regulation of apoptotic process negative regulation of JUN kinase activity peptidyl-serine phosphorylation transcription, DNA-templated phosphorylation apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10114 15259 Ensembl ENSG00000110422 ENSMUSG00000027177 UniProt Q9H422 Q9ERH7 RefSeq (mRNA) NM_001048200 NM_001278162 NM_001278163 NM_005734 NM_001145824 NM_010434 RefSeq (protein) NP_001041665 NP_001265091 NP_001265092 NP_005725 NP_001139296 NP_034564 Location (UCSC) Chr 11: 33.26 – 33.36 Mb Chr 2: 104.26 – 104.32 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Homeodomain-interacting protein kinase 3 is an enzyme that in humans is encoded by the HIPK3 gene.^[5][6][7]

References

1. GRCh38: Ensembl release 89: ENSG00000110422 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027177 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Begley DA, Berkenpas MB, Sampson KE, Abraham I (Dec 1997). "Identification and sequence of human PKY, a putative kinase with increased expression in multidrug-resistant cells, with homology to yeast protein kinase Yak1". Gene. 200 (1–2): 35–43. doi:10.1016/S0378-1119(97)00350-8. PMID 9373137.
6. Kim YH, Choi CY, Lee SJ, Conti MA, Kim Y (Nov 1998). "Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors". J Biol Chem. 273 (40): 25875–9. doi:10.1074/jbc.273.40.25875. PMID 9748262.
7. "Entrez Gene: HIPK3 homeodomain interacting protein kinase 3".

Further reading

• Moilanen AM, Karvonen U, Poukka H, et al. (1999). "Activation of Androgen Receptor Function by a Novel Nuclear Protein Kinase". Mol. Biol. Cell. 9 (9): 2527–43. doi:10.1091/mbc.9.9.2527. PMC 25523. PMID 9725910.
• Scaffidi C, Volkland J, Blomberg I, et al. (2000). "Phosphorylation of FADD/ MORT1 at serine 194 and association with a 70-kDa cell cycle-regulated protein kinase". J. Immunol. 164 (3): 1236–42. doi:10.4049/jimmunol.164.3.1236. PMID 10640736.
• Nupponen NN, Visakorpi T (2000). "Assignment of the protein kinase homolog of YAK1 (HIPK3) to human chromosome band 11p13 by in situ hybridization". Cytogenet. Cell Genet. 87 (1–2): 102–3. doi:10.1159/000015404. PMID 10640824. S2CID 5798220.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Minty A, Dumont X, Kaghad M, Caput D (2000). "Covalent modification of p73alpha by SUMO-1. Two-hybrid screening with p73 identifies novel SUMO-1-interacting proteins and a SUMO-1 interaction motif". J. Biol. Chem. 275 (46): 36316–23. doi:10.1074/jbc.M004293200. PMID 10961991.
• Rochat-Steiner V, Becker K, Micheau O, et al. (2000). "Fist/Hipk3: A FAS/Fadd-Interacting Serine/Threonine Kinase That Induces Fadd Phosphorylation and Inhibits FAS-Mediated Jun Nh2-Terminal Kinase Activation". J. Exp. Med. 192 (8): 1165–74. doi:10.1084/jem.192.8.1165. PMC 2311455. PMID 11034606.
• Curtin JF, Cotter TG (2004). "JNK regulates HIPK3 expression and promotes resistance to Fas-mediated apoptosis in DU 145 prostate carcinoma cells". J. Biol. Chem. 279 (17): 17090–100. doi:10.1074/jbc.M307629200. PMID 14766760.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
• Venables JP, Bourgeois CF, Dalgliesh C, et al. (2005). "Up-regulation of the ubiquitous alternative splicing factor Tra2beta causes inclusion of a germ cell-specific exon". Hum. Mol. Genet. 14 (16): 2289–303. doi:10.1093/hmg/ddi233. PMID 16000324.
• Taylor TD, Noguchi H, Totoki Y, et al. (2006). "Human chromosome 11 DNA sequence and analysis including novel gene identification". Nature. 440 (7083): 497–500. Bibcode:2006Natur.440..497T. doi:10.1038/nature04632. PMID 16554811.
• Lan HC, Li HJ, Lin G, et al. (2007). "Cyclic AMP Stimulates SF-1-Dependent CYP11A1 Expression through Homeodomain-Interacting Protein Kinase 3-Mediated Jun N-Terminal Kinase and c-Jun Phosphorylation". Mol. Cell. Biol. 27 (6): 2027–36. doi:10.1128/MCB.02253-06. PMC 1820514. PMID 17210646.

External links

• HIPK3 human gene location in the UCSC Genome Browser.
• HIPK3 human gene details in the UCSC Genome Browser.