Glucose-1-phosphate guanylyltransferase

glucose-1-phosphate guanylyltransferase
Identifiers
EC no.	2.7.7.34
CAS no.	9033-13-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a glucose-1-phosphate guanylyltransferase (EC 2.7.7.34) is an enzyme that catalyzes the chemical reaction

GTP + alpha-D-glucose 1-phosphate ${\displaystyle \rightleftharpoons }$ diphosphate + GDP-glucose

Thus, the two substrates of this enzyme are GTP and alpha-D-glucose 1-phosphate, whereas its two products are diphosphate and GDP-glucose.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is GTP:alpha-D-glucose-1-phosphate guanylyltransferase. Other names in common use include GDP glucose pyrophosphorylase, and guanosine diphosphoglucose pyrophosphorylase. This enzyme participates in starch and sucrose metabolism.

References

• Danishefsky I, Heritier-Watkins O (1967). "Nucleoside diphosphate glucose pyrophosphorylases in mast cell tumors". Biochim. Biophys. Acta. 139 (2): 349–57. doi:10.1016/0005-2744(67)90038-1. PMID 6034677.