Estradiol benzoate/testosterone propionate

Estradiol benzoate /
testosterone propionate
	Estradiol benzoate (top) and; testosterone propionate (bottom)
Combination of
Estradiol benzoate	Estrogen
Testosterone propionate	Androgen; Anabolic steroid
Clinical data
Trade names	Bothermon
Other names	EB/TP
Routes of; administration	Intramuscular injection
Identifiers
CAS Number	8055-33-2;

Estradiol benzoate/testosterone propionate (EB/TP), sold under the brand name Bothermon, is an injectable combination medication of estradiol benzoate (EB), an estrogen, and testosterone propionate (TP), an androgen/anabolic steroid.^[1]^[2]^[3]^[4]^[5] It contains 0.24 mg/mL EB and 4.76 mg/mL TP in oil solution in each ampoule and is administered by intramuscular injection.^[1] The medication was marketed in Japan by 1953^[4] and remains available in this country today.^[5]

v
t
e
Androgen replacement therapy formulations and dosages used in women
Route	Medication	Major brand names	Form	Dosage
Oral	Testosterone undecanoate	Andriol, Jatenzo	Capsule	40–80 mg 1x/1–2 days
	Methyltestosterone	Metandren, Estratest	Tablet	0.5–10 mg/day
	Fluoxymesterone	Halotestin	Tablet	1–2.5 mg 1x/1–2 days
	Normethandrone^a	Ginecoside	Tablet	5 mg/day
	Tibolone	Livial	Tablet	1.25–2.5 mg/day
	Prasterone (DHEA)^b	–	Tablet	10–100 mg/day
Sublingual	Methyltestosterone	Metandren	Tablet	0.25 mg/day
Transdermal	Testosterone	Intrinsa	Patch	150–300 μg/day
Transdermal	Testosterone	AndroGel	Gel, cream	1–10 mg/day
Vaginal	Prasterone (DHEA)	Intrarosa	Insert	6.5 mg/day
Injection	Testosterone propionate^a	Testoviron	Oil solution	25 mg 1x/1–2 weeks
	Testosterone enanthate	Delatestryl, Primodian Depot	Oil solution	25–100 mg 1x/4–6 weeks
	Testosterone cypionate	Depo-Testosterone, Depo-Testadiol	Oil solution	25–100 mg 1x/4–6 weeks
	Testosterone isobutyrate^a	Femandren M, Folivirin	Aqueous suspension	25–50 mg 1x/4–6 weeks
	Mixed testosterone esters	Climacteron^a	Oil solution	150 mg 1x/4–8 weeks
	Mixed testosterone esters	Omnadren, Sustanon	Oil solution	50–100 mg 1x/4–6 weeks
	Nandrolone decanoate	Deca-Durabolin	Oil solution	25–50 mg 1x/6–12 weeks
	Prasterone enanthate^a	Gynodian Depot	Oil solution	200 mg 1x/4–6 weeks
Implant	Testosterone	Testopel	Pellet	50–100 mg 1x/3–6 months
Notes: Premenopausal women produce about 230 ± 70 μg testosterone per day (6.4 ± 2.0 mg testosterone per 4 weeks), with a range of 130 to 330 μg per day (3.6–9.2 mg per 4 weeks). Footnotes: ^a = Mostly discontinued or unavailable. ^b = Over-the-counter. Sources: See template.

References

^ ^a ^b 伴一郎, & 杉山陽一. (1956). 男性ホルモンと黄体ホルモンとの混合製剤 Testoluton の使用成績. [Testoluton (Schering), A Combined Preparation of Testosterone Propionate and Progesterone Applied for Clinical Use] 産婦人科の進歩, 8(2), 100-103. https://www.jstage.jst.go.jp/article/sanpunosinpo1949/8/2/8_2_100/_pdf
^ 村上清. (1959). 産科婦人科的ホルモン療法の概況 (本邦). [Overview of obstetrics and gynecology hormone therapy (in Japan).] 産婦人科の進歩, 11(Special), 6-30. https://www.jstage.jst.go.jp/article/sanpunosinpo1949/11/Special/11_Special_6/_pdf
^ 山村博三. (1956). 機能性子宮出血の性ホルモン療法. [Sex hormone therapy for functional uterine bleeding.] 関西医科大学雑誌, 8(4), 293-299. https://www.jstage.jst.go.jp/article/jkmu1956/8/4/8_293/_pdf
^ ^a ^b 植田安雄, & 辻井翠. (1953). 月経困難症に対する Androgenestrogen 混合剤 Bothermon の応用 (治療成績). [Application of Androgenestrogen Bothermon for dysmenorrhea (treatment results).] ホルモンと臨床, 1(4), 333-337. https://ci.nii.ac.jp/naid/40018513715/
^ ^a ^b "Archived copy". Archived from the original on 2019-04-07. Retrieved 2019-06-09.{{cite web}}: CS1 maint: archived copy as title (link)