The stadium was one of those included in the Seville bids for the 2004 and 2008 Summer Olympics. After the failure of the last bid, the stadium remained unused by either of Seville's major football teams as both Real Betis and Sevilla use their own stadia. However, both teams have expressed their intention to move temporarily while their respective home grounds are renovated.
The Spain national football team occasionally use the stadium for home games, last playing there in 2023. The stadium has previously hosted the final of the Copa del Rey. Real Betis's home game against Villarreal on 31 March 2007 also took place here following a temporary ban from the Manuel Ruiz de Lopera.
The Royal Spanish Tennis Federation has chosen it twice to host the Davis Cup final, in 2004 and 2011. On both occasions a temporary roof was installed on one side of the stadium, where the clay court was placed.[3]
On 23 April 2021 it was announced that the stadium would replace San Mamés Stadium in Bilbao as a host stadium for UEFA Euro 2020, which was unable to fulfill its original hosting duties due to the COVID-19 pandemic.[5] During the tournament, and as part of the UEFA Festival, Seville was illuminated at night with a light show across the cityscape.[6]
It could host matches for the 2030 FIFA World Cup and is going to renovate until end of 2024 with 70,000 to 75,000 seats including new rows replacing unused running track.
On 9 October 1999, Mexican singer Luis Miguel performed a concert at the Stadium in front of 35,000 spectators during his Amarte Es Un Placer Tour.
On 16 September 2008, American entertainer Madonna played a concert in front of 47,712 spectators during her Sticky & Sweet Tour.
U2 performed at the stadium on 30 September 2010 during their U2 360° Tour, in front of a sold-out crowd of 76,159 people.
Depeche Mode were scheduled to perform at the stadium on 12 July 2009 as part of their Tour of the Universe, but the concert was cancelled due to singer Dave Gahan's leg injury.
^"Spain vs. Germany"(JSON). Union of European Football Associations. 17 November 2020. Retrieved 19 November 2020.
^"Spain vs. Kosovo"(JSON). Union of European Football Associations. 31 March 2021. Retrieved 1 April 2021.
^"Full Time Summary – Spain v Sweden"(PDF). UEFA.com. Union of European Football Associations. 14 June 2021. Archived(PDF) from the original on 16 June 2021. Retrieved 14 June 2021.
^"Full Time Summary – Spain v Poland"(PDF). UEFA.com. Union of European Football Associations. 19 June 2021. Archived(PDF) from the original on 14 June 2021. Retrieved 19 June 2021.
^"Spain vs. Sweden". Union of European Football Associations. 14 November 2021. Archived from the original on 19 November 2021. Retrieved 14 November 2021.