EPS8L1

EPS8L1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2K2M, 2ROL
Identifiers
Aliases	EPS8L1, DRC3, EPS8R1, PP10566, EPS8 like 1
External IDs	OMIM: 614987; MGI: 1914675; HomoloGene: 15767; GeneCards: EPS8L1; OMA:EPS8L1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.42 Start 55,072,020 bp[1] End 55,087,923 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A1 Start 4,463,673 bp[2] End 4,483,486 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube buccal mucosa cell skin of abdomen skin of leg amniotic fluid right lobe of thyroid gland left lobe of thyroid gland pancreatic ductal cell oral cavity minor salivary glands Top expressed in esophagus lip skin of external ear granulocyte conjunctival fornix skin of back neural layer of retina left lung lobe right lung lobe cornea More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin binding T cell receptor binding protein binding cadherin binding Cellular component ruffle membrane extracellular exosome cytoplasm cytosol plasma membrane protein-containing complex Biological process regulation of Rho protein signal transduction Rho protein signal transduction positive regulation of ruffle assembly regulation of molecular function Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54869 67425 Ensembl ENSG00000131037 ENSMUSG00000006154 UniProt Q8TE68 Q8R5F8 RefSeq (mRNA) NM_017729 NM_133180 NM_139204 NM_001290416 NM_026146 NM_001374622 RefSeq (protein) NP_060199 NP_573441 NP_001277345 NP_080422 NP_001361551 Location (UCSC) Chr 19: 55.07 – 55.09 Mb Chr 7: 4.46 – 4.48 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Epidermal growth factor receptor kinase substrate 8-like protein 1 is an enzyme that in humans is encoded by the EPS8L1 gene.^[5][6]

This gene encodes a protein that is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown. Several alternatively spliced transcript variants encoding different isoforms exist.^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000131037 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000006154 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tocchetti A, Confalonieri S, Scita G, Di Fiore PP, Betsholtz C (Mar 2003). "In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure". Genomics. 81 (2): 234–44. doi:10.1016/S0888-7543(03)00002-8. PMID 12620401.
6. "Entrez Gene: EPS8L1 EPS8-like 1".

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Offenhäuser N, Borgonovo A, Disanza A, et al. (2004). "The eps8 Family of Proteins Links Growth Factor Stimulation to Actin Reorganization Generating Functional Redundancy in the Ras/Rac Pathway". Mol. Biol. Cell. 15 (1): 91–8. doi:10.1091/mbc.E03-06-0427. PMC 307530. PMID 14565974.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wu K, Xu Z, Wang M, et al. (1999). "[Cloning and expression analyses of down-regulated cDNA C6-2A in human esophageal cancer]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 16 (5): 325–7. PMID 10514543.