Draft:Answer ALS

Submission declined on 18 May 2026 by Tacyarg (talk). Submitter has made no changes to the article since the last decline, which therefore still stands. If you would like to continue working on the submission, click on the "Edit" tab at the top of the window. If you have not resolved the issues listed above, your draft will be declined again and potentially deleted. If you need extra help, please ask us a question at the AfC Help Desk or get live help from experienced editors. Please do not remove reviewer comments or this notice until the submission is accepted. Where to get help If you need help editing or submitting your draft, please ask us a question at the AfC Help Desk or get live help from experienced editors. These venues are only for help with editing and the submission process, not to get reviews. If you need feedback on your draft, or if the review is taking a lot of time, you can try asking for help on the talk page of a relevant WikiProject. Some WikiProjects are more active than others so a speedy reply is not guaranteed. How to improve a draft Wikipedia:Contributing to Wikipedia – a basic overview on how to edit Wikipedia. Help:Wikitext – how to use the markup Help:Referencing for beginners – how to include references Wikipedia:Article development – how to develop your article Wikipedia:Writing better articles – how to improve your article Wikipedia:Verifiability – make sure your article includes reliable third-party sources You can also browse Wikipedia:Featured articles and Wikipedia:Good articles to find examples of Wikipedia's best writing on topics similar to your proposed article. Improving your odds of a speedy review To improve your odds of a faster review, tag your draft with relevant WikiProject tags using the button below. This will let reviewers know a new draft has been submitted in their area of interest. For instance, if you wrote about a female astronomer, you would want to add the Biography, Astronomy, and Women scientists tags. Add tags to your draft Editor resources Easy tools: Citation bot (help) | Advanced: Fix bare URLs Declined by Tacyarg 2 months ago. Last edited by Tacyarg 2 months ago. Reviewer: Inform author. Resubmit Please note that if the issues are not fixed, the draft will be declined again.

Submission declined on 18 May 2026 by Devonian Wombat (talk). This draft reads like an advertisement. Wikipedia is an encyclopedia, not a platform for promotion or marketing. Drafts that are exclusively promotional may be deleted without notice. Wikipedia articles must be written neutrally in a formal, impersonal, and dispassionate way. They should not read like a blog post, advertisement, or fan page. Rewrite the draft to remove: promotional language: see Words to watch; personal commentary: opinions or direct addresses to the reader; informal language. Instead, only summarize in your own words a range of independent, reliable, published sources that discuss the subject. If you have a conflict of interest (e.g. you are the subject, an employee, or a relative) or are being paid to edit, you must disclose this to comply with Wikipedia's Terms of Use. This draft's references do not show that the subject meets Wikipedia's criteria for inclusion for organizations and companies. The draft requires multiple published secondary sources that: provide significant coverage: discuss the subject in detail, excluding routine coverage like product launches, staff appointments, or financial reports and listings in databases or listicles; are reliable: from reputable outlets with editorial oversight; are independent: not connected to the subject, such as press releases, the subject's own website, or sponsored content. Please add references that meet all three of these criteria. If none exist, the subject is not yet suitable for Wikipedia. Declined by Devonian Wombat 2 months ago.

Submission declined on 19 December 2025 by Pythoncoder (talk). Resubmitted without changes; previous decline still stands. Declined by Pythoncoder 7 months ago.

Submission declined on 1 December 2025 by Pythoncoder (talk). This draft appears to contain text generated by a large language model (such as ChatGPT). You cannot use LLMs to generate article content. LLM-generated pages with certain obvious signs of being machine generated may be deleted without notice. Instead, only summarize in your own words a range of independent, reliable, published sources that discuss the subject. See the advice page on large language models for more information. Declined by Pythoncoder 8 months ago.

Submission declined on 20 November 2025 by Pythoncoder (talk). Resubmitted without improvement; previous decline still stands. Declined by Pythoncoder 8 months ago.

Submission declined on 28 October 2025 by Cabrils (talk). This draft's references do not show that the subject meets Wikipedia's criteria for inclusion for organizations and companies. The draft requires multiple published secondary sources that: provide significant coverage: discuss the subject in detail, excluding routine coverage like product launches, staff appointments, or financial reports and listings in databases or listicles; are reliable: from reputable outlets with editorial oversight; are independent: not connected to the subject, such as press releases, the subject's own website, or sponsored content. Please add references that meet all three of these criteria. If none exist, the subject is not yet suitable for Wikipedia. Declined by Cabrils 9 months ago.

• Comment: Well done on creating the draft, and it may potentially meet the relevant requirements (including WP:GNG, WP:NCORP) but presently it is not clear that it does.
  As you may know, Wikipedia's basic requirement for entry is that the subject is notable. Essentially subjects are presumed notable if they have received significant coverage in multiple published secondary sources that are reliable, intellectually independent of each other, and independent of the subject. To properly create such a draft page, please see the articles ‘Your First Article’, ‘Referencing for Beginners’ and ‘Easier Referencing for Beginners’. In short, "notability" requires reliable sources about the subject, rather than by the subject.
  The logo image used likely breaches copyright, which Wikipedia takes seriously, so should be removed unless clear evidence of its legal use is provided. If it is indeed the draft's author's "Own work" then the author clearly knows the subject and has a conflict of interest that must be declared (see details below). It seems highly unlikely that it is the draft's author's "Own work", unless the author is also a professional graphic designer, but no such evidence has been provided.
  Please note that many of the references would appear to be from sources that are NOT considered reliable for establishing notability and should be removed (including blogs, company websites, press releases, Twitter, YouTube, Instagram, Spotify etc).
  Additionally, the draft tends to read too much like a promotional advertorial, which Wikipedia is not; and contains prose that is not of a standard appropriate for an encyclopaedia (also see WP:PEACOCK).
  Also, if you have any connection to the subject, including being an employee of the subject (see WP:AUTOBIO) or being paid, you have a conflict of interest that you must declare on your Talk page (to see instructions on how to do this please click the link). In instances of a conflict of interest, the review of the page needs to be handled with care, mindful of the higher bar set by pages produced in circumstances of such a conflict. Such pages typically may read too much like a promotional CV or advertorial, which Wikipedia is not; and/or contain prose that is not of a standard appropriate for an encyclopaedia (also see WP:PEACOCK and WP:NPV).
  Please familiarise yourself with these pages before amending the draft. If you feel you can meet these requirements, then please make the necessary amendments before resubmitting the page.
  It would help our volunteer reviewers by identifying, on the draft's talk page, the WP:THREE best sources that establish notability of the subject.
  It would also be helpful if you could please identify with specificity, exactly which criteria you believe the page meets (eg "I think the page now meets WP:NCORP criteria #3, because XXXXX").
  Once you have implemented these suggestions, you may also wish to leave a note for me on my talk page, including the name of the draft page, and I would be happy to reassess. Cabrils (talk) 05:29, 28 October 2025 (UTC)

Answer ALS is a United States-based research consortium and nonprofit focused on amyotrophic lateral sclerosis (ALS). It has enrolled more than 1,500 participants and created a resource that links longitudinal clinical data with multi-omics from induced pluripotent stem cell (iPSC) derived motor neurons. Data and matched biospecimens are made available to researchers through the Neuromine Data Portal and an iPSC repository operated with Cedars-Sinai.^[1][2][3][4]

Answer ALS grew out of the Team Gleason ALS Summit held in 2013, organized by former NFL player and New Orlean Saint Steve Gleason and his foundation, which convened researchers, clinicians, and advocates to draft a coordinated research plan.^[5][6] At the time, Answer ALS was described as a multi-year, 20-million-dollar research project involving Johns Hopkins, Cedars-Sinai, Massachusetts General Hospital and other centers.^{[7][AI-retrieved source]} Gleason publicly announced the “Answer ALS” initiative in June 2014, calling it “the single largest effort to end ALS in the history of the disease.”^[8] The nonprofit Answer ALS Foundation received U.S. tax-exempt status in 2015 and is headquartered in New Orleans, Louisiana.^[9]

Enrollments and data collection were coordinated across eight U.S. ALS clinics beginning in 2016. The design of the cohort, longitudinal measures and multi-omics paired with patient-derived neurons were outlined in a 2022 Nature Neuroscience resource paper.^[10] The enrolling clinics listed in the Nature Neuroscience paper are Johns Hopkins University; Massachusetts General Hospital, Healey & AMG Center for ALS; Ohio State University Wexner Medical Center; Emory University; Washington University in St. Louis; Northwestern University, Les Turner ALS Center; Cedars-Sinai Medical Center; and Texas Neurology in Dallas.^[10]

In November 2018, Microsoft announced a one million dollar contribution and Azure cloud support.^[11] In November 2024, Answer ALS and Cedars-Sinai reported public availability of a large patient-based ALS iPSC and biodata repository, with access via the Cedars-Sinai Biomanufacturing Center and the Neuromine portal.^{[12][13][14][15]}

The core Answer ALS cohort combines longitudinal in-clinic assessments with iPSC derived spinal motor neurons generated from participant blood cells. The associated multi-omics include whole-genome sequencing, RNA sequencing, proteomics, and epigenomics such as ATAC-seq, linked to matched biofluids and cell lines available to outside laboratories.^[10]

Answer ALS operates Neuromine, a data portal that provides controlled access to de-identified clinical data and multi-omics, with tools for cohort definition and visualization.^[16] In March 2024, ALS Therapy Development Institute announced a data sharing collaboration to incorporate ALS TDI datasets into Neuromine.^[17]

In late 2024, Answer ALS and Cedars-Sinai announced public availability of a patient-based iPSC and ALS biodata repository, with access through the Cedars-Sinai Biomanufacturing Center and Neuromine.^{[12][13][14][15]}

Large-scale differentiation and characterization of iPSC derived spinal motor neurons from ALS and control donors were reported in Neuron, 19 Apr 2023.^[18] Chromatin accessibility in more than 500 iPSC derived motor neuron lines and prediction of clinical progression rates were reported in Nature Communications, 2 May 2024^[19]. MIT News summarized the epigenomic analysis and implications on 2 May 2024.^[20]

In August 2025, Answer ALS, ALS Therapy Development Institute, and Augie's Quest announced Champion Insights,^{[21] [22]}a remote participation study intended to investigate why athletes, military service members, and other high-performing groups show elevated incidences of ALS, with data planned for open sharing through the Neuromine Data Portal.^[23][24][25] The combined dataset and cell bank is one of the largest resources for ALS research, with over 1,800 iPSC lines distributed to more than 130 institutions worldwide.^[26]

Jeffrey D. Rothstein is co-founder and executive director of the research program in institutional profiles and reporting.^[27][28] Clare Durrett serves as managing director.^[12][29][30]

Answer ALS is a 501(c)(3) organization with tax-exempt status since 2015.^[9]

Amyotrophic lateral sclerosis

Induced pluripotent stem cell

open science