DIPK2B

79742

DIPK2B
DIPK2B
Identifiers
AliasesDIPK2B, 4930578C19Rik, DIA1R, EPQL1862, PRO3743, bA435K1.1, chromosome X open reading frame 36, CXorf36, divergent protein kinase domain 2B
External IDsOMIM: 300959; MGI: 1923155; GeneCards: DIPK2B
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

79742

75905

Ensembl

ENSG00000147113

ENSMUSG00000037358

UniProt

Q9H7Y0

Q8C3I9

RefSeq (mRNA)

NM_024689
NM_176819

NM_175228

RefSeq (protein)

NP_078965
NP_789789

NP_780437

Location (UCSC)Chr X: 45.15 – 45.2 MbChr X: 18.28 – 18.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Divergent protein kinase domain 2B is a protein which in humans is encoded by the gene DIPK2B (previously CXorf36). This protein is most highly expressed in the placenta and fat tissues, and it is predicted that this protein is extracellular, but otherwise the function is not currently very well understood.[5][6] A notable homolog is DIPK2A.[7]

Gene

The location of the DIPK2B gene on chromosome X

It can be transcribed into 8 different transcript variants, which in turn can produce 6 different isoforms of the protein.[8]

The genomic DNA is 52,529 base pairs long,[5] while the longest mRNA that it produces is 4,735 bases long.

Gene Neighborhood

DIPK2B is closely surrounded by the following genes on chromosome X:[5]

  • DUSP21
  • KDM6A
  • MIR222
  • TBX20

DIPK2B is also surrounded by two other genes on chromosome X that have been implicated in X-linked mental retardation.[9]

Protein

The longest protein isoform that is produced by the DIPK2B gene is termed hypothetical protein LOC79742 isoform 1 and is 433 amino acids long.[10]

Expression

DIPK2B is shown to be expressed ubiquitously at low levels in various tissues throughout the body. It is expressed highly in the ciliary ganglion, ovary, and uterus corpus. However, highest expression is seen in the trigeminal ganglion tissue.[11]

Conservation

DIPK2B has one paralog in humans known as DIPK2A.[12] Orthologs have been found in all mammals and through numerous eukaryotes.[13] However, conservation of the full gene halts past this, most likely a result of duplication from the ancestral gene into DIPK2B and DIPK2A. The full list of organisms in which orthologs have been found is given below.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000147113 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037358 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c "DIPK2B divergent protein kinase domain 2B". Retrieved 2026-07-31.
  6. ^ Thiselton DL, McDowall J, Brandau O, Ramser J, d'Esposito F, Bhattacharya SS, Ross MT, Hardcastle AJ, Meindl A (April 2002). "An integrated, functionally annotated gene map of the DXS8026-ELK1 interval on human Xp11.3-Xp11.23: potential hotspot for neurogenetic disorders". Genomics. 79 (4): 560–72. doi:10.1006/geno.2002.6733. PMID 11944989.
  7. ^ "Q9H7Y0 · DIK2B_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-07-31.
  8. ^ "NCBI AceView: CXorf36". Retrieved 2011-04-28.
  9. ^ Tarpey PS, Smith R, Pleasance E, Whibley A, Edkins S, Hardy C, O'Meara S, Latimer C, Dicks E, Menzies A, Stephens P, Blow M, Greenman C, Xue Y, Tyler-Smith C, Thompson D, Gray K, Andrews J, Barthorpe S, Buck G, Cole J, Dunmore R, Jones D, Maddison M, Mironenko T, Turner R, Turrell K, Varian J, West S, Widaa S, Wray P, Teague J, Butler A, Jenkinson A, Jia M, Richardson D, Shepherd R, Wooster R, Tejada MI, Martinez F, Carvill G, Goliath R, de Brouwer AP, van Bokhoven H, Van Esch H, Chelly J, Raynaud M, Ropers HH, Abidi FE, Srivastava AK, Cox J, Luo Y, Mallya U, Moon J, Parnau J, Mohammed S, Tolmie JL, Shoubridge C, Corbett M, Gardner A, Haan E, Rujirabanjerd S, Shaw M, Vandeleur L, Fullston T, Easton DF, Boyle J, Partington M, Hackett A, Field M, Skinner C, Stevenson RE, Bobrow M, Turner G, Schwartz CE, Gecz J, Raymond FL, Futreal PA, Stratton MR (May 2009). "A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation". Nat. Genet. 41 (5): 535–43. doi:10.1038/ng.367. PMC 2872007. PMID 19377476.
  10. ^ "NCBI Protein: hypothetical protein LOC79742 isoform 1". Retrieved May 10, 2011.
  11. ^ "NCBI GEO Profiles: CXorf36". Retrieved May 10, 2011.
  12. ^ "KEGG: C3orf58". Retrieved May 10, 2011.
  13. ^ "NCBI BLAST". Retrieved May 9, 2011.

Further reading


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