DCTP deaminase (dUMP-forming)

DCTP deaminase (dUMP-forming)
Identifiers
EC no.	3.5.4.30
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

In enzymology, a dCTP deaminase (dUMP-forming) (EC 3.5.4.30) is an enzyme that catalyzes the chemical reaction

dCTP + 2 H₂O ${\displaystyle \rightleftharpoons }$ dUMP + diphosphate + NH₃

Thus, the two substrates of this enzyme are dCTP and H₂O, whereas its 3 products are dUMP, diphosphate, and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is dCTP aminohydrolase (dUMP-forming). This enzyme participates in pyrimidine metabolism.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2HXB, 2HXD, and 2HXE.

References

• Li H, Xu H, Graham DE, White RH (2003). "The Methanococcus jannaschii dCTP deaminase is a bifunctional deaminase and diphosphatase". J. Biol. Chem. 278 (13): 11100–6. doi:10.1074/jbc.M212460200. PMID 12538648.