The town also houses the headquarters of the Federal Railroad Administration's Office of Safety for Region 2, which governs Delaware, Maryland, New Jersey (from Camden south), Pennsylvania, Ohio, Virginia, West Virginia, and the District of Columbia.
Interstates 95 and 476 have an interchange in Crum Lynne. They form the southern and western boundaries, respectively. MacDade Boulevard is Crum Lynne's main east-to-west thoroughfare and parallels 95.