Corydaline synthase

corydaline synthase
Identifiers
EC no.	2.1.1.147
CAS no.	155807-67-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a corydaline synthase (EC 2.1.1.147) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + palmatine + 2 NADPH + H⁺ ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + corydaline + 2 NADP⁺

The 4 substrates of this enzyme are S-adenosyl methionine, palmatine, NADPH, and H⁺, whereas its 3 products are S-adenosylhomocysteine, corydaline, and NADP⁺.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:protoberberine 13-C-methyltransferase.

References

• Rueffer M, Bauer W, Zenk MH (1994). "The formation of corydaline and related alkaloids in Corydalis cava in vivo and in vitro". Can. J. Chem. 72: 170–175. doi:10.1139/v94-026.