Charles Peter DeLisi (born December 9, 1941) is an American biomedical scientist and the Metcalf Professor of Science and Engineering at Boston University. He is noted for major contributions to the initiation of the Human Genome Project,[8][9] for transformative academic leadership,[10] and for research contributions to mathematical and computational immunology,[11] cell biophysics,[12] genomics[13][5] and protein[14] and nucleic acid[15][16] structure and function. Recent activities include mathematical finance[17] and climate change.[18]
In 1969, he joined Donald Crothers’ laboratory as a National Institutes of Health (NIH) postdoctoralresearch fellow in the department of chemistry at Yale University. In 1972, he was appointed a theoretical division staff scientist at Los Alamos National Laboratory, where he collaborated with George Bell, a theoretical physicist who a few years earlier had begun pioneering research in mathematical immunology. DeLisi was subsequently appointed senior scientist (1975–1982) at the National Cancer Institute, NIH, and founding head of the Section on Theoretical Immunology (1982–1985), where he and his collaborators established one of the earliest protein and DNA sequence databases fully integrated with machine learning programs for functional inference[13] and developed a number of analytical methods that proved useful in cell biology.[11][20][14]
In 1986, as director of the U.S. Department of Energy's (DOE) Health and Environmental Research Programs, DeLisi and his advisors proposed the Human Genome Project to the White House Office of Management and Budget and the Congress. The proposal created much controversy but received strong endorsement from Alvin Trivelpiece, who was chief of DOE's Office of Science, and William Flynn Martin, the Deputy Secretary of Energy. It was included in President Ronald Reagan's fiscal year 1987 budget submission to the Congress and was approved subsequently by both the House of Representatives and the Senate, the latter with the essential endorsement of Senator Pete Domenici (R, NM).
During the spring of 1987, shortly before leaving the DOE, DeLisi established an ethical studies component of the Project.[21] The goal was to reserve 3-5% of the funding for scholars of the humanities and social sciences to develop a system of ethics that would inform decisions about the development and deployment of the radically new technologies destined to emerge from the completion of the Project.
In addition to the medical and scientific advances engendered by the Human Genome Project, it and its progeny have had a profound effect on research of cell biology. Computer scientists, in particular, transformed the topic and created a record of discovery destined to provide much material for studying the sociology of late 20th and early 21st century science. Computational and mathematical methods are now considered as important to progress in cell biology, a change that is forcing even the most conservative universities to develop new methods of biological education.[22] The Human Genome Project enabled a rapid transformation of DOE's health, environmental and energy programs, increasing considerably the importance of the Office of Health and Environmental Research.
Commemorating the significance of the Human Genome Project, the DOE installed a bronze plaque outside room F-202 at its Germantown, Maryland facility. The plaque is imprinted:[9]
From this room the Human Genome Project evolved from a mere concept to a revolutionary research program through the vision and determination of Dr. Charles DeLisi, Associate Director of Energy Research for Health and Environmental Research, 1985 to 1987.
In 1999 DeLisi initiated the nation's first Ph.D. program in bioinformatics and served as chairperson for more than a decade.[27]
In 2000, after 10 years as dean, DeLisi resumed a full-time faculty position as dean emeritus and Metcalf Professor. The lobby of the building that houses the College of Engineering Dean's Office is named in his honor,[28] as is an annual College of Engineering award lecture.[29]
^Human Genome News (Genomics.energy.gov) Vol.11, No. 3-4, July 2001.
^Bevatron’s Encyclopedia of Inventions: a compendium of technological leaps, ground break discoveries and scientific breakthroughs that changed the world. The Human Genome Project, Charles DeLisi, pp 360-362, ISBN 9781780873404.
^Weng, Zhiping (1997). Protein-ligand binding: Effective free energy calculations (PhD thesis). Boston University. OCLC38760266. ProQuest304338123.
^ abYanai, I., Derti, A., and DeLisi, C. Genes linked by fusion events are generally of the same functional category: A systematic analysis of 30 microbial genomes. PNAS, v 98, 7940-7945, 2001
^DeLisi, C.: Physical-Chemical and Biological Implications of Receptor Clustering. In DeLisi, C., and Blumenthal, R. (Ed.): Physical Chemical Aspects of Cell Surface Events in Cellular Regulation. New York, Elsevier, North Holland, 1979. ISBN 0444003118, 9780444003119.
^DeLisi, C., and Blumenthal, R. (Ed.): Physical Chemical Aspects of Cell Surface Events in Cellular Regulation. New York, Elsevier, North Holland, 1979
^ abKlein, Petr; Kanehisa, Minoru; DeLisi, Charles (1985). "The detection and classification of membrane-spanning proteins". Biochimica et Biophysica Acta (BBA) - Biomembranes. 815 (3): 468–476. doi:10.1016/0005-2736(85)90375-X. ISSN0005-2736. PMID3838905.
^DeLisi, C. and Crothers, D.M., Prediction of RNA Secondary Structure, Proc Nat Acad. Sci, 68, 2682-2685, 1972
^Nakata, K., Kanehisa, M., DeLisi, C. Prediction of Splice Junctions in mRNA, Nucleic Acid Research, 13(14), 5327-5340, 1985
^"Team". De Novo Analytics. Archived from the original on 2021-04-16. Retrieved 2021-04-16.
^DeLisi, C., Patrinos, A., MacCracken, M., et al The Role of Synthetic Biology in Atmospheric Greenhouse Gas Reduction, AAAS BioDesign Research, Volume 2020 |Article ID 1016207 | https://doi.org/10.34133/2020/1016207Archived 2024-04-29 at the Wayback Machine
