CatSper3

CATSPER3
Identifiers
Aliases	CATSPER3, CACRC, CatSper3, cation channel sperm associated 3
External IDs	OMIM: 609120; MGI: 1924106; HomoloGene: 12658; GeneCards: CATSPER3; OMA:CATSPER3 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.1 Start 134,967,907 bp[1] End 135,011,696 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 B1 Start 55,932,381 bp[2] End 55,956,811 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm right testis left testis testicle gonad gastrocnemius muscle muscle of thigh right uterine tube mucosa of transverse colon gastric mucosa Top expressed in spermatid seminiferous tubule embryo spermatocyte embryo primary oocyte muscle of thigh zygote proximal tubule digastric muscle More reference expression data BioGPS n/a
Gene ontology Molecular function voltage-gated calcium channel activity calcium channel activity voltage-gated ion channel activity ion channel activity cation channel activity Cellular component integral component of membrane CatSper complex cell projection membrane plasma membrane cilium acrosomal vesicle endoplasmic reticulum motile cilium Biological process flagellated sperm motility cell differentiation membrane depolarization during action potential sodium ion transport regulation of ion transmembrane transport ion transport multicellular organism development ion transmembrane transport calcium ion transmembrane transport transmembrane transport spermatogenesis sperm-egg recognition sperm capacitation calcium ion transport response to progesterone Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 347732 76856 Ensembl ENSG00000152705 ENSMUSG00000021499 UniProt Q86XQ3 Q80W99 RefSeq (mRNA) NM_178019 NM_001252487 NM_001252488 NM_029772 RefSeq (protein) NP_821138 NP_001239416 NP_001239417 NP_084048 Location (UCSC) Chr 5: 134.97 – 135.01 Mb Chr 13: 55.93 – 55.96 Mb PubMed search [3] [4]
Wikidata
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CatSper3, is a protein which in humans is encoded by the CATSPER3 gene.^[5][6][7][8] CatSper3 is a member of the cation channels of sperm family of proteins. The four proteins in this family together form a Ca²⁺-permeant ion channel specific essential for the correct function of sperm cells.^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000152705 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021499 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Arias JM, Murbartián J, Perez-Reyes E (March 2003). "Cloning of a novel one-repeat calcium channel-like gene". Biochem. Biophys. Res. Commun. 303 (1): 31–6. doi:10.1016/S0006-291X(03)00276-6. PMID 12646162.
6. Lobley A, Pierron V, Reynolds L, Allen L, Michalovich D (August 2003). "Identification of human and mouse CatSper3 and CatSper4 genes: Characterisation of a common interaction domain and evidence for expression in testis". Reprod. Biol. Endocrinol. 1: 53. doi:10.1186/1477-7827-1-53. PMC 184451. PMID 12932298.
7. Qi H, Moran MM, Navarro B, Chong JA, Krapivinsky G, Krapivinsky L, Kirichok Y, Ramsey IS, Quill TA, Clapham DE (January 2007). "All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility". Proc. Natl. Acad. Sci. U.S.A. 104 (4): 1219–23. doi:10.1073/pnas.0610286104. PMC 1770895. PMID 17227845.
8. Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101. S2CID 35096827.
9. *"CatSper and Two-Pore Channels: Introduction". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2012-09-05. Retrieved 2008-12-16.