CEP68

CEP68

CEP68
Identifiers
AliasesCEP68, KIAA0582, centrosomal protein 68
External IDsOMIM: 616889; MGI: 2667663; GeneCards: CEP68
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

23177

216543

Ensembl

ENSG00000011523

ENSMUSG00000044066

UniProt

Q76N32

Q8C0D9

RefSeq (mRNA)

NM_015147
NM_001319100
NM_001319101

NM_172260

RefSeq (protein)

NP_001306029
NP_001306030
NP_055962

NP_758464

Location (UCSC)Chr 2: 65.06 – 65.09 MbChr 11: 20.18 – 20.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Centrosomal protein of 68 kDa is a protein that in humans is encoded by the CEP68 gene.[5][6][7][8] CEP68 is required for centrosome cohesion. It decorates fibres emanating from the proximal ends of centrioles. During mitosis, CEP68 dissociates from centrosomes. CEP68 and rootletin depend on each other for centriole association, and both also require CEP250 for their function.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000011523 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044066 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, et al. (February 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (1): 31–39. doi:10.1093/dnares/5.1.31. PMID 9628581.
  6. ^ The Sanger Centre, The Washington University Genome Sequencing Center (November 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–1108. doi:10.1101/gr.8.11.1097. PMID 9847074.
  7. ^ Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (December 2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–574. Bibcode:2003Natur.426..570A. doi:10.1038/nature02166. PMID 14654843. S2CID 4427303.
  8. ^ "Entrez Gene: CEP68 centrosomal protein 68kDa".
  9. ^ Graser S, Stierhof YD, Nigg EA (December 2007). "Cep68 and Cep215 (Cdk5rap2) are required for centrosome cohesion". Journal of Cell Science. 120 (Pt 24): 4321–4331. doi:10.1242/jcs.020248. PMID 18042621. S2CID 7307094.

Further reading

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