CEP57

CEP57
Identifiers
Aliases	CEP57, MVA2, PIG8, TSP57, centrosomal protein 57
External IDs	OMIM: 607951; MGI: 1915551; GeneCards: CEP57
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4L0R
Gene location (Human)
Chr.	Chromosome 11 (human)
End	95,832,693 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	13,738,403 bp
RNA expression pattern
	Top expressed in
	oocyte; ; Achilles tendon; ; sperm; ; ganglionic eminence; ; secondary oocyte; ; gallbladder; ; hair follicle; ; ventricular zone; ; Epithelium of choroid plexus; ; cartilage tissue;
	Top expressed in
	seminiferous tubule; ; hand; ; spermatid; ; genital tubercle; ; tail of embryo; ; spermatocyte; ; ventricular zone; ; epiblast; ; abdominal wall; ; thymus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; microtubule binding; protein binding; identical protein binding; fibroblast growth factor binding; gamma-tubulin binding;
Cellular component	cytosol; centrosome; Golgi apparatus; microtubule organizing center; microtubule; cytoskeleton; nucleus; cytoplasm; microtubule cytoskeleton; nucleoplasm;
Biological process	fibroblast growth factor receptor signaling pathway; microtubule anchoring; G2/M transition of mitotic cell cycle; spermatid development; mitotic sister chromatid segregation; protein homooligomerization; ciliary basal body-plasma membrane docking; regulation of G2/M transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	9702
	74360
	ENSG00000166037
	ENSMUSG00000031922
	Q86XR8
	Q8CEE0
	NM_001243776; NM_001243777; NM_014679; NM_001363604
	NM_026665; NM_001310721
	NP_001230705; NP_001230706; NP_055494; NP_001350533
	NP_001297650; NP_080941
	Wikidata
View/Edit Human	View/Edit Mouse

Centrosomal protein of 57 kDa is a protein that in humans is encoded by the CEP57 gene.^[5]^[6] It is also known as translokin.

Translokin binds basic fibroblast growth factor (FGF2; MIM 134920) and mediates its nuclear translocation and mitogenic activity (Bossard et al., 2003).[supplied by OMIM]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166037 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031922 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H, et al. (Jul 1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
^ ^a ^b "Entrez Gene: CEP57 centrosomal protein 57kDa".

External links

Human CEP57 genome location and CEP57 gene details page in the UCSC Genome Browser.
PDBe-KB provides an overview of all the structure information available in the PDB for Human Centrosomal protein of 57 kDa

Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins". Exp. Cell Res. 259 (1): 239–46. doi:10.1006/excr.2000.4948. PMID 10942595.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Bossard C, Laurell H, Van den Berghe L, et al. (2003). "Translokin is an intracellular mediator of FGF-2 trafficking". Nat. Cell Biol. 5 (5): 433–9. doi:10.1038/ncb979. PMID 12717444. S2CID 21792653.
Kim YS, Nakanishi G, Oudes AJ, et al. (2004). "Tsp57: a novel gene induced during a specific stage of spermatogenesis". Biol. Reprod. 70 (1): 106–13. doi:10.1095/biolreprod.103.018465. PMID 12954732.
Andersen JS, Wilkinson CJ, Mayor T, et al. (2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. Bibcode:2003Natur.426..570A. doi:10.1038/nature02166. PMID 14654843. S2CID 4427303.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ahn J, Chung KS, Kim DU, et al. (2005). "Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus". J. Biochem. Mol. Biol. 37 (6): 741–8. doi:10.5483/bmbrep.2004.37.6.741. PMID 15607035.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000166037 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031922 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7788527-5] Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H, et al. (Jul 1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.

[entrez-6] "Entrez Gene: CEP57 centrosomal protein 57kDa".

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v t e The centrosome and its components
Centrioles	SASS6 CENPJ CNTROB CEP104 Centrins (CETN1, CETN2 and CETN3) SFI1
Pericentriolar material	BBS4 LCK PCM1 PCNT TNKS TNKS2 TUBE1
other proteins	CCP110 CEP55 CEP57 CEP63 CEP68 CEP70 CEP72 CEP76 CEP78 CEP90 CEP97 CEP120 CEP135 CEP152 CEP164 CEP170 CEP192 CEP215 CEP250 CEP350 CNTRL NIN NINL

CEP57

References

External links

Further reading

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