Aminoglycoside N3'-acetyltransferase

aminoglycoside N3'-acetyltransferase
Identifiers
EC no.	2.3.1.81
CAS no.	60120-42-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, an aminoglycoside N3'-acetyltransferase (EC 2.3.1.81) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + a 2-deoxystreptamine antibiotic ${\displaystyle \rightleftharpoons }$ CoA + N₃'-acetyl-2-deoxystreptamine antibiotic

Thus, the two substrates of this enzyme are acetyl-CoA and 2-deoxystreptamine antibiotic, whereas its two products are CoA and N3'-acetyl-2-deoxystreptamine antibiotic.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:2-deoxystreptamine-antibiotic N3'-acetyltransferase. Other names in common use include 3'-aminoglycoside acetyltransferase, and 3-N-aminoglycoside acetyltransferase.

References

• Davies J, O'Connor S (1978). "Enzymatic modification of aminoglycoside antibiotics: 3-N-acetyltransferase with broad specificity that determines resistance to the novel aminoglycoside apramycin". Antimicrob. Agents Chemother. 14 (1): 69–72. doi:10.1128/aac.14.1.69. PMC 352406. PMID 356726.