Alkylhalidase

alkylhalidase
Identifiers
EC no.	3.8.1.1
CAS no.	9025-22-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, an alkylhalidase (EC 3.8.1.1) is an enzyme that catalyzes the chemical reaction

bromochloromethane + H₂O ${\displaystyle \rightleftharpoons }$ formaldehyde + bromide + chloride

Thus, the two substrates of this enzyme are bromochloromethane and H₂O, whereas its 3 products are formaldehyde, bromide, and chloride.

This enzyme belongs to the family of hydrolases, specifically those acting on halide bonds in carbon-halide compounds. The systematic name of this enzyme class is alkyl-halide halidohydrolase. Other names in common use include halogenase, haloalkane halidohydrolase, and haloalkane dehalogenase.

References

• Heppel LA, Porterfield VT (November 1948). "Enzymatic dehalogenation of certain brominated and chlorinated compounds" (PDF). The Journal of Biological Chemistry. 176 (2): 763–9. PMID 18889931.

Further reading

• Damborský, Jiří; et al. (2003). "Rational Redesign of Haloalkane Dehalogenases by Comparative Binding Energy Analysis". In Svendsen, Allan (ed.). Enzyme Functionality: Design: Engineering, and Screening. CRC Press. ISBN 9780203913048. OCLC 839656924.