Syedna Abduttayyeb Zakiuddin was born in Wankaner. He was only three years of age when his father Syedna Ismail Badruddin II died. The 39th Dā'i Syedna Ibrahim Wajiuddin took him under his care. Syedna Wajiuddin gave his granddaughter Khadija AaiSaheba binte Syedna Hebatullah-il-Moayed Fiddeen in marriage to Syedna Abduttayyeb Zakiuddin. After Khadija AaSaheba died, Syedna Wajiuddin gave his granddaughter Ratan AaiSaheba binte Syedi Khan BhaiSaheb in marriage to Syedna Abduttayyeb Zakiuddin. By this marriage, Syedna Abduttayyeb Zakiuddin had four sons; the 42nd Dā'i Syedna Yusuf Najmuddin, Syedna Abde Ali Saifuddin, Syedi Sheikh Adam Safiyuddin and Syedi Abdul Qadir Hakimuddin.
Accession
Syedna Zakiuddin became Da'i al-Mutlaq in 1193AH/1780 AD.[2] His period of Dawat was from 1193–1200 AH/1780–1787 AD.
His associates were: Mawazeen: Syedi Sheikh Adam Safiyuddin, Yusuf Najmuddin and Mukasir: Syedna Abdeali Saifuddin
He ordered building of a Haveli (a royal palace) in Burhanpur. The Haveli was built in the royal classical Rajasthani style with exquisite carvings, and engravings. The Haveli was built in 1197 AH. Syedna Zakiuddin visited Burhanpur in 1199 AH and resided in the Haveli and then adopted Burhanpur as the Capital of Dawat.