65536 is the smallest number with exactly 17 divisors (but there are smaller numbers with more than 17 divisors; e.g., 180 has 18 divisors) (sequence A005179 in the OEIS).
A 16-bit number can distinguish 65536 different possibilities. For example, unsignedbinary notation exhausts all possible 16-bit codes in uniquely identifying the numbers 0 to 65535. In this scheme, 65536 is the least natural number that can not be represented with 16 bits. Conversely, it is the "first" or smallest positive integer that requires 17 bits.
65536 is the only power of 2 less than 231000 that does not contain the digits 1, 2, 4, or 8 in its decimal representation.[2]
The default buffer size of a Unix pipeline is 64KiB (65536 bytes).
65536 is the maximum number of spreadsheet rows supported by Excel 97, Excel 2000, Excel 2002 and Excel 2003. Text files that are larger than 65536 rows cannot be imported to these versions of Excel.[5] (Excel 2007, 2010 and 2013 support 1,048,576 rows (220)).
A 16-bit microprocessor chip can directly access 65536 memory addresses, and the 16-bit highcolor graphics standard supports a color palette of 65536 different colors.
The maximum number of methods allowed in a single dex file Android application is 65536.[6]
The limit for the amount of code in bytes for a non-native, non-abstract method in Java.