5-hydroxyfuranocoumarin 5-O-methyltransferase

5-hydroxyfuranocoumarin 5-O-methyltransferase
Identifiers
EC no.	2.1.1.69
CAS no.	101637-31-4&title= 67339-12-2, 101637-31-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

5-hydroxyfuranocoumarin 5-O-methyltransferase (EC 2.1.1.69, furanocoumarin 5-methyltransferase, furanocoumarin 5-O-methyltransferase, bergaptol 5-O-methyltransferase, bergaptol O-methyltransferase, bergaptol methyltransferase, S-adenosyl-L-methionine:bergaptol O-methyltransferase, BMT, S-adenosyl-L-methionine:5-hydroxyfuranocoumarin 5.1-O-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:5-hydroxyfurocoumarin 5-O-methyltransferase.^[1][2][3][4] This enzyme catalyses the following chemical reaction

(1) S-adenosyl-L-methionine + a 5-hydroxyfurocoumarin ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + a 5-methoxyfurocoumarin (general reaction)

(2) S-adenosyl-L-methionine + bergaptol ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + bergapten

The enzyme methylates the 5-hydroxy group of some hydroxy- and methylcoumarins, such as 5-hydroxyxanthotoxin.

References

1. Thompson HJ, Sharma SK, Brown SA (June 1978). "O-methyltransferases of furanocoumarin biosynthesis". Archives of Biochemistry and Biophysics. 188 (2): 272–81. doi:10.1016/s0003-9861(78)80009-5. PMID 28084.
2. Sharma SK, Garrett JM, Brown SA (1979). "Separation of the S-adenosylmethionine: 5- and 8-hydroxyfuranocoumarin O-methyltransferases of Ruta graveolens L. by general ligand affinity chromatography". Zeitschrift für Naturforschung C. 34C (5–6): 387–91. doi:10.1515/znc-1979-5-611. PMID 156999.
3. Hauffe, K.D.; Hahlbrock, K.; Scheel, D. (1986). "Elicitor-stimulated furanocoumarin biosynthesis in cultured parsley cells - S-adenosyl-L-methionine-bergaptol and S-adenosyl-L-methionine-xanthotoxol O-methyltransferases". Zeitschrift für Naturforschung C. 41: 228–239. doi:10.1515/znc-1986-1-234.
4. Hehmann M, Lukacin R, Ekiert H, Matern U (March 2004). "Furanocoumarin biosynthesis in Ammi majus L. Cloning of bergaptol O-methyltransferase". European Journal of Biochemistry. 271 (5): 932–40. doi:10.1111/j.1432-1033.2004.03995.x. PMID 15009205.

External links

• 5-hydroxyfuranocoumarin+5-O-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)