4-Dimethylallyltryptophan N-methyltransferase

4-dimethylallyltryptophan N-methyltransferase
Identifiers
EC no.	2.1.1.261
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

4-dimethylallyltryptophan N-methyltransferase (EC 2.1.1.261, fgaMT (gene), easF (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:4-(3-methylbut-2-enyl)-L-tryptophan N-methyltransferase.^[1] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + 4-dimethylallyl-L-tryptophan ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + 4-dimethylallyl-L-abrine

The enzyme catalyses a step in the pathway leading to biosynthesis of ergot alkaloids in certain fungi.

References

1. Rigbers O, Li SM (October 2008). "Ergot alkaloid biosynthesis in Aspergillus fumigatus. Overproduction and biochemical characterization of a 4-dimethylallyltryptophan N-methyltransferase". The Journal of Biological Chemistry. 283 (40): 26859–68. doi:10.1074/jbc.m804979200. PMID 18678866.

External links

• 4-dimethylallyltryptophan+N-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)