3-oxosteroid 1-dehydrogenase

3-oxosteroid 1-dehydrogenase
Identifiers
EC no.	1.3.99.4
CAS no.	9029-04-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a 3-oxosteroid 1-dehydrogenase (EC 1.3.99.4) is an enzyme that catalyzes the chemical reaction

a 3-oxosteroid + acceptor ${\displaystyle \rightleftharpoons }$ a 3-oxo-Delta₁-steroid + reduced acceptor

Thus, the two substrates of this enzyme are 3-oxosteroid and acceptor, whereas its two products are 3-oxo-Delta1-steroid and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is 3-oxosteroid:acceptor Delta1-oxidoreductase. Other names in common use include 3-oxosteroid Delta1-dehydrogenase, Delta1-dehydrogenase, 3-ketosteroid-1-en-dehydrogenase, 3-ketosteroid-Delta1-dehydrogenase, 1-ene-dehydrogenase, 3-oxosteroid:(2,6-dichlorphenolindophenol) Delta1-oxidoreductase, 4-en-3-oxosteroid:(acceptor)-1-en-oxido-reductase, Delta1-steroid reductase, and 3-oxosteroid:(acceptor) Delta1-oxidoreductase.

References

• LEVY HR, TALALAY P (1959). "Bacterial oxidation of steroids. II. Studies on the enzymatic mechanism of ring A dehydrogenation". J. Biol. Chem. 234 (8): 2014–21. PMID 13673006.