27S pre-rRNA (guanosine2922-2'-O)-methyltransferase

27S pre-rRNA (guanosine^2922-2'-O)-methyltransferase
Identifiers
EC no.	2.1.1.167
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

27S pre-rRNA (guanosine²⁹²²-2'-O)-methyltransferase (EC 2.1.1.167, Spb1p (gene), YCL054W (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:27S pre-rRNA (guanosine²⁹²²-2'-O-)-methyltransferase.^[1][2] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + guanosine²⁹²² in 27S pre-rRNA ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + 2'-O-methylguanosine²⁹²² in 27S pre-rRNA

Spb1p is a site-specific 2'-O-ribose RNA methyltransferase that catalyses the formation of 2'-O-methylguanosine2922.

References

1. Lapeyre B, Purushothaman SK (November 2004). "Spb1p-directed formation of Gm2922 in the ribosome catalytic center occurs at a late processing stage". Molecular Cell. 16 (4): 663–9. doi:10.1016/j.molcel.2004.10.022. PMID 15546625.
2. Bonnerot C, Pintard L, Lutfalla G (November 2003). "Functional redundancy of Spb1p and a snR52-dependent mechanism for the 2'-O-ribose methylation of a conserved rRNA position in yeast". Molecular Cell. 12 (5): 1309–15. doi:10.1016/S1097-2765(03)00435-0. PMID 14636587.

External links

• 27S+pre-rRNA+(guanosine2922-2'-O)-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)