23S rRNA (guanine1835-N2)-methyltransferase

23S rRNA (guanine^1835-N^2)-methyltransferase
Identifiers
EC no.	2.1.1.174
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

23S rRNA (guanine¹⁸³⁵-N²)-methyltransferase (EC 2.1.1.174, ygjO (gene), rlmG (gene), ribosomal RNA large subunit methyltransferase G) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (guanine¹⁸³⁵-N²)-methyltransferase.^[1] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + guanine¹⁸³⁵ in 23S rRNA ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + N²-methylguanine¹⁸³⁵ in 23S rRNA

The enzyme methylates 23S rRNA in vitro, assembled 50S subunits are not a substrate.

References

1. Sergiev PV, Lesnyak DV, Bogdanov AA, Dontsova OA (November 2006). "Identification of Escherichia coli m2G methyltransferases: II. The ygjO gene encodes a methyltransferase specific for G1835 of the 23 S rRNA". Journal of Molecular Biology. 364 (1): 26–31. doi:10.1016/j.jmb.2006.09.008. PMID 17010380.

External links

• 23S+rRNA+(guanine1835-N2)-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)