The twelve teams that advanced from the second round (the seven group winners excluding Qatar and the five best group runners-up) were divided into two groups of six teams to play home-and-away round-robin matches. The top two teams of each group qualified for the 2022 FIFA World Cup, and the two third-placed teams advanced to the fourth round. World Cup hosts Qatar won Group E in the second round (which meant they advanced to the 2023 AFC Asian Cup finals) but were not required to qualify for the World Cup.
Due to the COVID-19 pandemic in Asia, FIFA announced on 12 August 2020 that the upcoming qualifying matches originally scheduled for 2020 were moved to 2021,[7] and on 11 November, the AFC Competitions Committee also announced that the final round of the Asian qualifiers would begin in September 2021 and be finished by March 2022.[8]
^On the AFC's official YouTube page, "The AFC Hub," it is referred to as the Final Round.
^This would usually be a "Best 4", but because the 2022 FIFA World Cup hosts Qatar won their group (their participation in the second round was to secure a spot in the 2023 AFC Asian Cup), the draw for the third round of the FIFA World Cup's qualification included 5 runners-up instead.[4]
^Qatar had already qualified for the 2022 FIFA World Cup as the tournament hosts, but competed in the second round as part of the 2023 AFC Asian Cup qualification.