The draw took place on 8 September 2022.[4] Former Greek professional footballer and current manager, Tasos Tasiopoulos, made the draw using a manually operated lotery ball cage.
The draw took place on 11 October 2022.[6] Former Greek international and current football manager, Sakis Tsiolis, made the draw using a manually operated lottery ball cage.
Each tie in the knockout phase, apart from the quarter-finals and the semi-finals, was played by a single match. If the score was level at the end of normal time, extra time was played, followed by a penalty shoot-out if the score was still level. In the quarter-finals and the semi-finals were played over two legs, with each team playing one leg at home. The team that scored more goals on aggregate over the two legs advanced to the next round. If the aggregate score was level, the away goals rule was applied, i.e. the team that scored more goals away from home over the two legs advanced. If away goals were also equal, then extra time was played. The away goals rule was again applied after extra time, i.e. if there were goals scored during extra time and the aggregate score was still level, the visiting team advanced by virtue of more away goals scored. If no goals were scored during extra time, the winners were decided by a penalty shoot-out. In the round of 16, if the score was level at the end of normal time the two-legged rule was applied. The mechanism of the draws for each round is as follows:
In the draw for the Round of 16, the four Super League clubs finishing in places 1–4 in the previous season are seeded, while the clubs advancing from the Fifth Round are unseeded. The seeded teams are drawn against the unseeded teams, with the seeded teams hosting the second leg. The remaining 8 unseeded clubs will be drawn against one another with the team being drawn last hosting the second leg.
In the draws for the quarter-finals onwards, there are no seedings and teams from the same group can be drawn against each other.
The draw took place on 14 November 2022.[7] Former Greek international and member of the UEFA Euro 2004 squad, Antonios Nikopolidis, made the draw using a manually operated lottery ball cage.