The 2021–22 season was the 77th season in the existence of VfL Wolfsburg and the club's 25th consecutive season in the top flight of German football. In addition to the domestic league, VfL Wolfsburg participated in this season's editions of the DFB-Pokal and the UEFA Champions League, after finishing fourth in the previous Bundesliga season.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
Note: The match originally ended 3–1 for Wolfsburg after extra time. Wolfsburg used a total of six substitutes, while only five were allowed, and were disqualified after a protest by Preußen Münster.[32]