The 2021–22 season was FC Zürich's 126th season in existence and the club's fifth consecutive season in the top flight of Swiss football. In addition to the domestic league, Zürich participated in this season's editions of the Swiss Cup.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.
Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply. Players may hold more than one non-FIFA nationality.