The 2010 Waratah Cup (known as the 2010 McDonald's Cup for sponsorship reasons) was the seventh edition of the knockout competition since its re-introduction in 2004 and the 30th all-time premier state cup since inauguration in 1957.
Three matches kick started the 2010 McDonald's Cup campaign on Wednesday 31 March after as many as seven games were cancelled due to wet weather conditions that gripped Sydney. In the three matches St George Association based Sans Souci defeated Eastern Suburbs based Association side Pagewood Botany 2–1 in what was a fiercely contested match. State League Two new boys Belmore Hercules had their work cut out but managed to defeat Bankstown Association's Bankstown Sports Strikers 2–1 at Crest while at Seymour Shaw State League Two side Fairfield Wanderers easily disposed of Sutherland Association's Bangor Junior 5–0. Daniel Gonzalez was the hero for the Wanderers after hitting a first half hat-trick while there were also goals from Sanchez and Olvarez.