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The 2007–08 Second and Third Division Knock-Out (known as quick Keno Second and Third Division Knock-Out for sponsorship reasons) was a knockout tournament for Maltese football clubs playing in the Second and Third Division. The final was contested by defending champions, Balzan Youths and Melita, the latter winning 5–1.

Group stage

Pos	Team	Pld	W	D	L	GF	GA	GD	Pts	Qualification	MLT	STA	MTF	KKP
1	Melita	3	3	0	0	19	2	+17	9	Advance to knockout phase	—	1–0	10–2	8–0
2	St. Andrews	3	1	1	1	5	4	+1	4			—	1–1	4–2
3	Mtarfa	3	0	2	1	4	12	−8	2				—	1–1
4	Kirkop United	3	0	2	1	3	13	−10	2					—

Pos	Team	Pld	W	L	GF	GA	GD	Pts	Qualification	MĠR	NXR	MDN	LQA
1	Mġarr United	3	3	0	4	1	+3	9	Advance to knockout phase	—	1–0	2–1	1–0
2	Naxxar Lions	3	2	1	8	2	+6	6			—	5–0	3–1
3	Mdina Knights	3	1	2	4	7	−3	3				—	3–0
4	Luqa St. Andrew's	3	0	3	1	7	−6	0					—

Pos	Team	Pld	W	D	L	GF	GA	GD	Pts	Qualification	RBT	BBĠ	FGR	GŻR
1	Rabat Ajax	3	2	1	0	7	3	+4	7	Advance to knockout phase	—	1–1	4–1	2–1
2	Birżebbuġa St. Peter's	3	1	2	0	3	2	+1	5			—	0–0	2–1
3	Fgura United	3	1	1	1	2	4	−2	4				—	1–0
4	Gżira United	3	0	0	3	2	5	−3	0					—

Pos	Team	Pld	W	D	L	GF	GA	GD	Pts	Qualification	BZN	SĠW	ATD	GDJ
1	Balzan Youths	3	2	1	0	3	0	+3	7	Advance to knockout phase	—	0–0	2–0	1–0
2	San Ġwann	3	1	1	1	2	1	+1	4			—	0–1	2–0
3	Attard	3	1	1	1	2	3	−1	4				—	1–1
4	Gudja United	3	0	1	2	1	4	−3	1					—

Pos	Team	Pld	W	D	L	GF	GA	GD	Pts	Qualification	GXQ	LJA	ŻBĠ	SLC
1	Għaxaq	3	2	1	0	10	1	+9	7	Advance to knockout phase	—	3–0	1–1	6–0
2	Lija Athletic	3	1	1	1	7	5	+2	4			—	1–1	6–1
3	Żebbuġ Rangers	3	0	3	0	3	3	0	3				—	1–1
4	St. Lucia	3	0	1	2	2	13	−11	1					—

Pos	Team	Pld	W	D	L	GF	GA	GD	Pts	Qualification	ŻRQ	SĠW	GĦR	ŻTN
1	Żurrieq	3	2	1	0	7	4	+3	7	Advance to knockout phase	—	4–2	2–1	1–1
2	Siġġiewi	3	2	0	1	7	6	+1	6			—	3–1	2–1
3	Għargħur	3	1	0	2	4	5	−1	3				—	2–0
4	Żejtun Corinthians	3	0	1	2	2	5	−3	1					—

Pos	Team	Pld	W	D	L	GF	GA	GD	Pts	Qualification	SVN	QRD	KKR
1	St. Venera Lightnings	2	1	1	0	9	0	+9	4	Advance to knockout phase	—	0–0	9–0
2	Qrendi	2	1	1	0	2	1	+1	4			—	2–1
3	Kalkara	2	0	0	2	1	11	−10	0				—

Pos	Team	Pld	W	D	L	GF	GA	GD	Pts	Qualification	XJR	SIR	PBK
1	Xgħajra Tornadoes	2	1	1	0	2	1	+1	4	Advance to knockout phase	—	0–0	2–1
2	Sirens	2	0	2	0	2	2	0	2			—	2–2
3	Pembroke Athleta	2	0	1	1	3	4	−1	1				—