2-hydroxychromene-2-carboxylate isomerase

2-hydroxychromene-2-carboxylate isomerase
Identifiers
EC no.	5.99.1.4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

2-hydroxychromene-2-carboxylate isomerase (EC 5.99.1.4, HCCA isomerase, 2HC2CA isomerase, 2-hydroxychromene-2-carboxylic acid isomerase) is an enzyme with systematic name 2-hydroxy-2H-chromene-2-carboxylate---(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate isomerase.^[1][2][3][4] This enzyme catalyses the following chemical reaction

2-hydroxy-2H-chromene-2-carboxylate ${\displaystyle \rightleftharpoons }$ (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate

This enzyme is involved in naphthalene degradation.

References

1. Ohmoto T, Kinoshita T, Moriyoshi K, Sakai K, Hamada N, Ohe T (September 1998). "Purification and some properties of 2-hydroxychromene-2-carboxylate isomerase from naphthalenesulfonate-assimilating Pseudomonas sp. TA-2". Journal of Biochemistry. 124 (3): 591–7. doi:10.1093/oxfordjournals.jbchem.a022152. PMID 9722670.
2. Keck A, Conradt D, Mahler A, Stolz A, Mattes R, Klein J (July 2006). "Identification and functional analysis of the genes for naphthalenesulfonate catabolism by Sphingomonas xenophaga BN6". Microbiology. 152 (Pt 7): 1929–40. doi:10.1099/mic.0.28783-0. PMID 16804169.
3. Eaton RW (December 1994). "Organization and evolution of naphthalene catabolic pathways: sequence of the DNA encoding 2-hydroxychromene-2-carboxylate isomerase and trans-o-hydroxybenzylidenepyruvate hydratase-aldolase from the NAH7 plasmid". Journal of Bacteriology. 176 (24): 7757–62. doi:10.1128/jb.176.24.7757-7762.1994. PMC 197239. PMID 8002605.
4. Thompson LC, Ladner JE, Codreanu SG, Harp J, Gilliland GL, Armstrong RN (June 2007). "2-Hydroxychromene-2-carboxylic acid isomerase: a kappa class glutathione transferase from Pseudomonas putida". Biochemistry. 46 (23): 6710–22. doi:10.1021/bi700356u. PMID 17508726.

External links

• 2-hydroxychromene-2-carboxylate+isomerase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)