2-dehydro-3-deoxyglucarate aldolase

2-dehydro-3-deoxyglucarate aldolase
2-dehydro-3-deoxyglucarate aldolase hexamer, Staphylococcus aureus
Identifiers
EC no.	4.1.2.20
CAS no.	37290-56-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The enzyme 2-dehydro-3-deoxyglucarate aldolase (EC 4.1.2.20) catalyzes the chemical reaction

2-dehydro-3-deoxy-D-glucarate ${\displaystyle \rightleftharpoons }$ pyruvate + tartronate semialdehyde

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase (pyruvate-forming). Other names in common use include 2-keto-3-deoxyglucarate aldolase, alpha-keto-beta-deoxy-D-glucarate aldolase, and 2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase. This enzyme participates in ascorbate and aldarate metabolism.

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1DXE, 1DXF, 1W37, 1W3I, 1W3N, and 1W3T.

References

• Fish DC, Blumenthal HJ (1966). "2-Keto-3-deoxy-D-glucarate aldolase". Carbohydrate Metabolism. Methods in Enzymology. Vol. 9. pp. 529–534. doi:10.1016/0076-6879(66)09105-5. ISBN 978-0-12-181809-8.