2-Polyprenyl-6-hydroxyphenol methylase

2-polyprenyl-6-hydroxyphenol methylase
Identifiers
EC no.	2.1.1.222
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

2-polyprenyl-6-hydroxyphenol methylase (EC 2.1.1.222, ubiG (gene), ubiG methyltransferase, 2-octaprenyl-6-hydroxyphenol methylase) is an enzyme with systematic name S-adenosyl-L-methionine:3-(all-trans-polyprenyl)benzene-1,2-diol 2-O-methyltransferase.^[1][2] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + 3-(all-trans-polyprenyl)benzene-1,2-diol ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + 2-methoxy-6-(all-trans-polyprenyl)phenol

UbiG catalyses both methylation steps in ubiquinone biosynthesis in Escherichia coli.

References

1. Poon WW, Barkovich RJ, Hsu AY, Frankel A, Lee PT, Shepherd JN, Myles DC, Clarke CF (July 1999). "Yeast and rat Coq3 and Escherichia coli UbiG polypeptides catalyze both O-methyltransferase steps in coenzyme Q biosynthesis". The Journal of Biological Chemistry. 274 (31): 21665–72. doi:10.1074/jbc.274.31.21665. PMID 10419476.
2. Hsu AY, Poon WW, Shepherd JA, Myles DC, Clarke CF (July 1996). "Complementation of coq3 mutant yeast by mitochondrial targeting of the Escherichia coli UbiG polypeptide: evidence that UbiG catalyzes both O-methylation steps in ubiquinone biosynthesis". Biochemistry. 35 (30): 9797–806. doi:10.1021/bi9602932. PMID 8703953.

External links

• 2-polyprenyl-6-hydroxyphenyl+methylase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)