2-Hydroxymuconate-6-semialdehyde dehydrogenase

2-Hydroxymuconate-6-semialdehyde dehydrogenase
Identifiers
EC no.	1.2.1.85
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

2-Hydroxymuconate-6-semialdehyde dehydrogenase (EC 1.2.1.85, xylG [gene], praB [gene] ) is an enzyme with systematic name (2E,4Z)-2-hydroxy-6-oxohexa-2,4-dienoate:NAD⁺ oxidoreductase.^[1][2][3] This enzyme catalyses the following chemical reaction

2-hydroxymuconate-6-semialdehyde + NAD⁺ + H₂O ${\displaystyle \rightleftharpoons }$ (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NADH + 2 H⁺

This substrate for this enzyme is formed by meta ring cleavage of catechol (EC 1.13.11.2, catechol 2,3-dioxygenase), and is an intermediate in the bacterial degradation of several aromatic compounds.

References

1. Inoue J, Shaw JP, Rekik M, Harayama S (March 1995). "Overlapping substrate specificities of benzaldehyde dehydrogenase (the xylC gene product) and 2-hydroxymuconic semialdehyde dehydrogenase (the xylG gene product) encoded by TOL plasmid pWW0 of Pseudomonas putida". Journal of Bacteriology. 177 (5): 1196–201. PMC 176723. PMID 7868591.
2. Orii C, Takenaka S, Murakami S, Aoki K (November 2006). "Metabolism of 4-amino-3-hydroxybenzoic acid by Bordetella sp. strain 10d: A different modified meta-cleavage pathway for 2-aminophenols". Bioscience, Biotechnology, and Biochemistry. 70 (11): 2653–61. doi:10.1271/bbb.60264. PMID 17090920.
3. Kasai D, Fujinami T, Abe T, Mase K, Katayama Y, Fukuda M, Masai E (November 2009). "Uncovering the protocatechuate 2,3-cleavage pathway genes". Journal of Bacteriology. 191 (21): 6758–68. doi:10.1128/JB.00840-09. PMC 2795304. PMID 19717587.

External links

• 2-hydroxymuconate-6-semialdehyde+dehydrogenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)