2,2-dialkylglycine decarboxylase (pyruvate)

2,2-dialkylglycine decarboxylase (pyruvate)
Identifiers
EC no.	4.1.1.64
CAS no.	9032-17-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The enzyme 2,2-dialkylglycine decarboxylase (pyruvate) (EC 4.1.1.64) catalyzes the chemical reaction

2,2-dialkylglycine + pyruvate ${\displaystyle \rightleftharpoons }$ dialkyl ketone + CO₂ + L-alanine

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 2,2-dialkylglycine carboxy-lyase (amino-transferring L-alanine-forming). Other names in common use include dialkyl amino acid (pyruvate) decarboxylase, alpha-dialkyl amino acid transaminase, 2,2-dialkyl-2-amino acid-pyruvate aminotransferase, L-alanine-alpha-ketobutyrate aminotransferase, dialkylamino-acid decarboxylase (pyruvate), and 2,2-dialkylglycine carboxy-lyase (amino-transferring). It employs one cofactor, pyridoxal phosphate.

Structural studies

As of late 2007, 16 structures have been solved for this class of enzymes, with PDB accession codes 1D7R, 1D7S, 1D7U, 1D7V, 1DGD, 1DGE, 1DKA, 1M0N, 1M0O, 1M0P, 1M0Q, 1Z3Z, 1ZC9, 1ZOB, 1ZOD, and 2DKB.

References

• Bailey GB, Dempsey WB (1967). "Purification and properties of an alpha-dialkyl amino acid transaminase". Biochemistry. 6 (5): 1526–1533. doi:10.1021/bi00857a039.