2'''-acetyl-6'''-hydroxyneomycin C deacetylase

2'''-acetyl-6'''-hydroxyneomycin C deacetylase
Identifiers
EC no.	3.5.1.113
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

2'''-acetyl-6'''-hydroxyneomycin C deacetylase (EC 3.5.1.113, neoL (gene)) is an enzyme with systematic name 2'''-acetyl-6'''-hydroxyneomycin C hydrolase (acetate-forming).^[1] This enzyme catalyses the following chemical reaction

2'''-acetyl-6'''-deamino-6'''-hydroxyneomycin C + H₂O ${\displaystyle \rightleftharpoons }$ 6'''-deamino-6'''-hydroxyneomycin C + acetate

This enzyme is involved in biosynthesis of aminoglycoside antibiotics of the [neomycin] family.

References

1. Yokoyama K, Yamamoto Y, Kudo F, Eguchi T (April 2008). "Involvement of two distinct N-acetylglucosaminyltransferases and a dual-function deacetylase in neomycin biosynthesis". ChemBioChem. 9 (6): 865–9. doi:10.1002/cbic.200700717. PMID 18311744.

External links

• '"`UNIQ--nowiki-00000015-QINU`"'-hydroxyneomycin C deacetylase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)