16S rRNA (cytidine1409-2'-O)-methyltransferase

16S rRNA (cytidine^1409-2'-O)-methyltransferase
Identifiers
EC no.	2.1.1.227
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

16S rRNA (cytidine¹⁴⁰⁹-2'-O)-methyltransferase (EC 2.1.1.227, TlyA) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (cytidine¹⁴⁰⁹-2'-O)-methyltransferase.^[1][2] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + cytidine¹⁴⁰⁹ in 16S rRNA ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + 2'-O-methylcytidine1⁴⁰⁹ in 16S rRNA

The bifunctional enzyme from Mycobacterium tuberculosis.

References

1. Johansen SK, Maus CE, Plikaytis BB, Douthwaite S (July 2006). "Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2'-O-methylations in 16S and 23S rRNAs". Molecular Cell. 23 (2): 173–82. doi:10.1016/j.molcel.2006.05.044. PMID 16857584.
2. Maus CE, Plikaytis BB, Shinnick TM (February 2005). "Mutation of tlyA confers capreomycin resistance in Mycobacterium tuberculosis". Antimicrobial Agents and Chemotherapy. 49 (2): 571–7. doi:10.1128/AAC.49.2.571-577.2005. PMC 547314. PMID 15673735.

External links

• 16S+rRNA+(cytidine1409-2'-O)-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)