1-alkyl-2-acetylglycerol O-acyltransferase

1-alkyl-2-acetylglycerol O-acyltransferase
Identifiers
EC no.	2.3.1.125
CAS no.	114704-90-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a 1-alkyl-2-acetylglycerol O-acyltransferase (EC 2.3.1.125) is an enzyme that catalyzes the chemical reaction

acyl-CoA + 1-O-alkyl-2-acetyl-sn-glycerol ${\displaystyle \rightleftharpoons }$ CoA + 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol

Thus, the two substrates of this enzyme are acyl-CoA and 1-O-alkyl-2-acetyl-sn-glycerol, whereas its two products are CoA and 1-O-alkyl-2-acetyl-3-acyl-sn-glycerol.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol O-acyltransferase. This enzyme is also called 1-hexadecyl-2-acetylglycerol acyltransferase. This enzyme participates in ether lipid metabolism.

References

• Kawasaki T, Snyder F (1988). "Synthesis of a novel acetylated neutral lipid related to platelet-activating factor by acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol acyltransferase in HL-60 cells". J. Biol. Chem. 263 (6): 2593–6. PMID 3422635.