(pyruvate dehydrogenase (acetyl-transferring))-phosphatase

[pyruvate dehydrogenase (lipoamide)] phosphatase
Identifiers
EC no.	3.1.3.43
CAS no.	9073-70-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The enzyme [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase (EC 3.1.3.43) catalyzes the reaction

[pyruvate dehydrogenase (acetyl-transferring)] phosphate + H₂O ${\displaystyle \rightleftharpoons }$ [pyruvate dehydrogenase (acetyl-transferring)] + phosphate

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name is [pyruvate dehydrogenase (acetyl-transferring)]-phosphate phosphohydrolase. Other names in common use include pyruvate dehydrogenase phosphatase, phosphopyruvate dehydrogenase phosphatase, [pyruvate dehydrogenase (lipoamide)]-phosphatase, and [pyruvate dehydrogenase (lipoamide)]-phosphate phosphohydrolase.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2PNQ.

References

• Linn TC, Pelley JW, Pettit FH, Hucho F, Randall DD, Reed LJ (1972). "α-Keto acid dehydrogenase complexes. XV. Purification and properties of the component enzymes of the pyruvate dehydrogenase complexes from bovine kidney and heart". Arch. Biochem. Biophys. 148 (2): 327–42. doi:10.1016/0003-9861(72)90151-8. PMID 4401694.
• Reed LJ, Damuni Z, Merryfield ML (1985). "Regulation of mammalian pyruvate and branched-chain α-keto acid dehydrogenase complexes by phosphorylation-dephosphorylation". Curr. Top. Cell. Regul. Current Topics in Cellular Regulation. 27: 41–9. doi:10.1016/b978-0-12-152827-0.50011-6. ISBN 9780121528270. PMID 3004826.