CCL12

MCP-1-related chemokine, Monocyte chemoattractant protein 5, Monocyte chemotactic protein 5, MCP-5

C-C motif chemokine 12
Andere Namen

MCP-1-related chemokine, Monocyte chemoattractant protein 5, Monocyte chemotactic protein 5, MCP-5

Masse/Länge Primärstruktur 104 Aminosäuren, 11.659 Da
Bezeichner
Externe IDs
Vorkommen
Homologie-Familie Hovergen

C-C motif chemokine 12 (CCL12) ist ein Protein aus der Gruppe der Chemokine in Ratten und Mäusen.

Eigenschaften

CCL12 wird in den Lymphknoten und im Thymus gebildet.[1][2] Es ist chemoattraktiv für Eosinophile, Monozyten und Lymphozyten,[1] nicht aber für Neutrophile. CCL12 bindet an CCR2 und ist beteiligt an der Allergie und der Pathogenabwehr. CCL12 besitzt zwei Disulfidbrücken. Sein Gen liegt in Mäusen auf Chromosom 11.[2]

Einzelnachweise

  1. ↑ a b Jia G, Gonzalo J, Lloyd C, Kremer L, Lu L, Martinez-A C, Wershil B, Gutierrez-Ramos J: Distinct expression and function of the novel mouse chemokine monocyte chemotactic protein-5 in lung allergic inflammation. In: J Exp Med. 184. Jahrgang, Nr. 5, 1996, S. 1939–51, doi:10.1084/jem.184.5.1939, PMID 8920881, PMC 2192876 (freier Volltext) – (englisch).
  2. ↑ a b Sarafi M, Garcia-Zepeda E, MacLean J, Charo I, Luster A: Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1. In: J Exp Med. 185. Jahrgang, Nr. 1, 1997, S. 99–109, doi:10.1084/jem.185.1.99, PMID 8996246, PMC 2196097 (freier Volltext) – (englisch).

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