MECP2

MECP2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1QK9, 3C2I
Dynodwyr
Cyfenwau	MECP2, AUTSX3, MRX16, MRX79, MRXS13, MRXSL, PPMX, RS, RTS, RTT, methyl-CpG binding protein 2
Dynodwyr allanol	OMIM: 300005 HomoloGene: 3657 GeneCards: MECP2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • double-stranded methylated DNA binding • GO:0001106 transcription corepressor activity • protein domain specific binding • protein N-terminus binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • transcription factor binding • siRNA binding • mRNA binding • chromatin binding • GO:0001948, GO:0016582 protein binding • DNA binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • RNA binding • methyl-CpG binding Cydrannau o'r gell • postsynapse • cytoplasm • mitocondria • cnewyllyn cell • GO:0035328 heterochromatin • extracellular space • gamma-tubulin complex • centrosome • cytosol • chromatin • nucleoplasm Prosesau biolegol • GO:1904089 negative regulation of neuron apoptotic process • multicellular organismal response to stress • inositol metabolic process • mitochondrial electron transport, ubiquinol to cytochrome c • post-embryonic development • learning • propriodderbyniaeth • neuron projection development • regulation of gene expression by genetic imprinting • GO:0009373 regulation of transcription, DNA-templated • pathogenesis • neuromuscular process controlling posture • adult locomotory behavior • Cof • transcription, DNA-templated • ventricular system development • neuron maturation • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • glutamine metabolic process • neuromuscular process • histone acetylation • excitatory postsynaptic potential • nervous system process involved in regulation of systemic arterial blood pressure • social behavior • synapse assembly • chemical synaptic transmission • negative regulation of histone methylation • startle response • glucocorticoid metabolic process • dendrite development • GO:1901227 negative regulation of transcription by RNA polymerase II • behavioral fear response • respiratory gaseous exchange by respiratory system • cerebellum development • regulation of synaptic plasticity • cardiolipin metabolic process • neuron differentiation • regulation of gene expression • sensory perception of pain • GO:0045996 negative regulation of transcription, DNA-templated • phosphatidylcholine metabolic process • visual learning • GO:0034613 protein localization • response to hypoxia • regulation of gene expression, epigenetic • cellular biogenic amine metabolic process • regulation of respiratory gaseous exchange by nervous system process • brain development • long-term memory • histone methylation • negative regulation of histone acetylation • catecholamine secretion • long-term potentiation • positive regulation of synapse assembly • negative regulation of smooth muscle cell differentiation • positive regulation of histone H3-K9 trimethylation • negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation • GO:0043148 mitotic spindle organization • locomotory behavior • positive regulation of cell population proliferation • response to radiation • positive regulation of G2/M transition of mitotic cell cycle • positive regulation of microtubule nucleation • transcription initiation from RNA polymerase II promoter • negative regulation of gene expression • negative regulation of angiogenesis • negative regulation of blood vessel endothelial cell migration • positive regulation of DNA methylation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	4204	n/a
Ensembl	ENSG00000169057	n/a
UniProt	P51608	n/a
RefSeq (mRNA)	NM_001110792 NM_004992 NM_001316337 NM_001369391 NM_001369392 NM_001369393 NM_001369394 NM_001386137 NM_001386138 NM_001386139	n/a
RefSeq (protein)	NP_001104262 NP_001303266 NP_004983 NP_001356320 NP_001356321 NP_001356322 NP_001356323	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn MECP2 yw MECP2 a elwir hefyd yn Methyl-CpG binding protein 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom X dynol, band Xq28.^[2]

Mae MECP2 yn cael ei ffosfforyleiddio gan MSK1 mewn proses a gaiff ei chyfryngu gan BDNF.^[3]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn MECP2.

• "Clinical and molecular genetic characterization of familial MECP2 duplication syndrome in a Chinese family. ". BMC Med Genet. 2017. PMID 29141583.
• "Biophysical characterization of the basic cluster in the transcription repression domain of human MeCP2 with AT-rich DNA. ". Biochem Biophys Res Commun. 2018. PMID 29101034.
• "MECP2 expression in gastric cancer and its correlation with clinical pathological parameters. ". Medicine (Baltimore). 2017. PMID 28767600.
• "MeCP2, A Modulator of Neuronal Chromatin Organization Involved in Rett Syndrome. ". Adv Exp Med Biol. 2017. PMID 28523538.
• "Potential role of DNA methylation as a facilitator of target search processes for transcription factors through interplay with methyl-CpG-binding proteins.". Nucleic Acids Res. 2017. PMID 28486614.