BDNF

BDNF
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1BND, 1B8M
Dynodwyr
Cyfenwau	BDNF, brain-derived neurotrophic factor, ANON2, BULN2, Brain-derived neurotrophic factor, brain derived neurotrophic factor
Dynodwyr allanol	OMIM: 113505 HomoloGene: 7245 GeneCards: BDNF
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • signaling receptor binding • neurotrophin TRKB receptor binding • growth factor activity • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • cytoplasm • perinuclear region of cytoplasm • mitocondria • nuclear speck • GO:0016023 cytoplasmic vesicle • extracellular region • extracellular space • synaptic vesicle • axon • dendrite Prosesau biolegol • brain-derived neurotrophic factor receptor signaling pathway • GO:1904089 negative regulation of neuron apoptotic process • synapse assembly • cell-cell signaling • positive regulation of brain-derived neurotrophic factor receptor signaling pathway • collateral sprouting • positive regulation of synapse assembly • positive regulation of collateral sprouting • nervous system development • axon guidance • negative regulation of myotube differentiation • positive regulation of receptor binding • regulation of protein localization to cell surface • regulation of signaling receptor activity • activation of phospholipase C activity • neurotrophin TRK receptor signaling pathway • positive regulation of non-membrane spanning protein tyrosine kinase activity • transmembrane receptor protein tyrosine kinase signaling pathway • peripheral nervous system development • Cof • nerve development • nerve growth factor signaling pathway • regulation of neuron differentiation • neuron projection morphogenesis • modulation of chemical synaptic transmission • positive regulation of neuron projection development • negative regulation of apoptotic signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	627	n/a
Ensembl	ENSG00000176697	n/a
UniProt	P23560	n/a
RefSeq (mRNA)	NM_001143805 NM_001143806 NM_001143807 NM_001143808 NM_001143809 NM_001143810 NM_001143811 NM_001143812 NM_001143813 NM_001143814 NM_001143815 NM_001143816 NM_001709 NM_170731 NM_170732 NM_170733 NM_170734 NM_170735	n/a
RefSeq (protein)	NP_001137277 NP_001137278 NP_001137279 NP_001137280 NP_001137281 NP_001137282 NP_001137283 NP_001137284 NP_001137285 NP_001137286 NP_001137288 NP_001700 NP_733927 NP_733928 NP_733929 NP_733930 NP_733931	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn BDNF yw BDNF a elwir hefyd yn Brain derived neurotrophic factor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11p14.1.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn BDNF.

• ANON2
• BULN2

• "The association between serum brain-derived neurotrophic factor and a cluster of cardiovascular risk factors in adolescents: The CHAMPS-study DK. ". PLoS One. 2017. PMID 29028824.
• "Genetics association study and functional analysis on osteoporosis susceptibility gene BDNF. ". Yi Chuan. 2017. PMID 28903900.
• "[Association of Val66Met polymorphism of brain-derived neurotrophic factor gene with cognitive impairment and clinical symptoms in first episode schizophrenia]. ". Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2017. PMID 28777866.
• "Brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism is associated with disease severity and incidence of cardiovascular events in a patient cohort. ". Am Heart J. 2017. PMID 28760212.
• "Evidence of associations between brain-derived neurotrophic factor (BDNF) serum levels and gene polymorphisms with tinnitus.". Noise Health. 2017. PMID 28615544.