VPS26B

VPS26B
Identifikatori
Aliasi	VPS26B
Vanjski ID-jevi	OMIM: 610027 MGI: 1917656 HomoloGene: 3601 GeneCards: VPS26B
Lokacija gena (čovjek) Hrom. Hromosom 11 (čovjek)[1] Bend 11q25 Početak 134,224,671 bp[1] Kraj 134,247,788 bp[1]
Lokacija gena (miš) Hrom. Hromosom 9 (miš)[2] Bend 9|9 A4 Početak 26,919,067 bp[2] Kraj 26,941,361 bp[2]
Ontologija gena Molekularna funkcija • GO:0001948, GO:0016582 vezivanje za proteine Ćelijska komponenta • citoplazma • retromer complex • late endosome • early endosome • membrana • retromer, cargo-selective complex • endozom • citosol • phagocytic vesicle Biološki proces • protein transport • retrograde transport, endosome to Golgi • regulation of macroautophagy • intracellular protein transport • cellular response to interferon-gamma • GO:0072468 Transdukcija signala Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	112936	69091
Ensembl	ENSG00000151502	ENSMUSG00000031988
UniProt	Q4G0F5	Q8C0E2
RefSeq (mRNK)	NM_052875	NM_178027
RefSeq (bjelančevina)	NP_443107 NP_443107.1	NP_821170
Lokacija (UCSC)	Chr 11: 134.22 – 134.25 Mb	Chr 9: 26.92 – 26.94 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Homolog B vakuolskog sortirajućeg proteina 26 (S. pombe) jest protein koji je kod ljudi kodiran genom VPS26B. ^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 336 aminokiselina, а molekulska težina 39.155 Da.^[6]

• C: Cistein
• D: Asparaginska kiselina
• E: Glutaminska kiselina
• F: Fenilalanin
• G: Glicin
• H: Histidin
• I: Izoleucin
• K: Lizin
• L: Leucin
• M: Metionin
• N: Asparagin
• P: Prolin
• Q: Glutamin
• R: Arginin
• S: Serin
• T: Treonin
• V: Valin
• W: Triptofan
• Y: Tirozin

10		20		30		40		50
MSFFGFGQSV		EVEILLNDAE		SRKRAEHKTE		DGKKEKYFLF		YDGETVSGKV
SLALKNPNKR		LEHQGIKIEF		IGQIELYYDR		GNHHEFVSLV		KDLARPGEIT
QSQAFDFEFT		HVEKPYESYT		GQNVKLRYFL		RATISRRLND		VVKEMDIVVH
TLSTYPELNS		SIKMEVGIED		CLHIEFEYNK		SKYHLKDVIV		GKIYFLLVRI
KIKHMEIDII		KRETTGTGPN		VYHENDTIAK		YEIMDGAPVR		GESIPIRLFL
AGYELTPTMR		DINKKFSVRY		YLNLVLIDEE		ERRYFKQQEV		VLWRKGDIVR
KSMSHQAAIA		SQRFEGTTSL		GEVRTPSQLS		DNNCRQ

Reference

1. GRCh38: Ensembl release 89: ENSG00000151502 - Ensembl, maj 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031988 - Ensembl, maj 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Vacuolar protein sorting 26 homolog B (S. pombe)".
6. "UniProt, Q4G0F5". Pristupljeno 29. 8. 2021.

Dopunska literatura

• Haft CR, de la Luz Sierra M, Bafford R, Lesniak MA, Barr VA, Taylor SI (decembar 2000). "Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes". Mol. Biol. Cell. 11 (12): 4105–16. doi:10.1091/mbc.11.12.4105. PMC 15060. PMID 11102511.
• Kerr MC, Bennetts JS, Simpson F, Thomas EC, Flegg C, Gleeson PA, Wicking C, Teasdale RD (novembar 2005). "A novel mammalian retromer component, Vps26B". Traffic. 6 (11): 991–1001. doi:10.1111/j.1600-0854.2005.00328.x. PMID 16190980. S2CID 31954489.